ArticleAmerican journal of obstetrics and gynecology2009
Trophoblast infection with Chlamydia pneumoniae and adverse pregnancy outcomes associated with placental dysfunction.
Article in American journal of obstetrics and gynecology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 33 citations in OpenAlex.
- Association between history of miscarriage and autism spectrum disorder.European archives of psychiatry and clinical neuroscience · 2023Article
- Perinatal Outcomes Among Patients With Sepsis During Pregnancy.JAMA network open · 2021Article
- Low-Dose Aspirin May Prevent Trophoblast Dysfunction in Women With Chlamydia Pneumoniae Infection.Reproductive sciences (Thousand Oaks, Calif.) · 2019Article
- Article
- Human infectious diseases and risk of preeclampsia: an updated review of the literature.Infection · 2017Review
- Immunological Tolerance, Pregnancy, and Preeclampsia: The Roles of Semen Microbes and the Father.Frontiers in medicine · 2017Article
- PrenatalPregnancy hypertension · 2013Article
- Nod1, but not the ASC inflammasome, contributes to induction of IL-1β secretion in human trophoblasts after sensing of Chlamydia trachomatis.Mucosal immunology · 2013Article
- Pathogens and the placental fortress.Current opinion in microbiology · 2012Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
objectiveWe sought to determine whether Chlamydia pneumoniae impairs invasive trophoblast function and is associated with preeclampsia. STUDY
designWe conducted cell viability and invasion assays using primary extravillous trophoblast cells isolated from first-trimester placentas. We performed a case-control study to identify C pneumoniae in trophoblast cells dissected by laser capture microscopy from placentas in women with severe preeclampsia and control subjects who delivered at term.
resultsTrophoblast cell viability and invasion through extracellular matrices were decreased after infection with C pneumoniae (both P < .05). C pneumoniae DNA was detected in trophoblast cells in 15/48 cases but only 3/30 controls (odds ratio, 4.1; P = .02). Positive and negative controls yielded expected results.
conclusionC pneumoniae infection can reduce trophoblast invasion into the uterine wall and is associated with preeclampsia. Further investigation of the mechanisms by which C pneumoniae induces trophoblast dysfunction, and the identification of therapies to prevent adverse outcomes attributed to trophoblast dysfunction, are warranted.
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Registered trials
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