ArticleNeurochemistry international2009
Involvement of oxidative pathways in cytokine-induced secretory phospholipase A2-IIA in astrocytes.
Article in Neurochemistry international, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 42 citations in OpenAlex.
- Diversified Effects of COVID-19 as a Consequence of the Differential Metabolism of Phospholipids and Lipid Peroxidation Evaluated in the Plasma of Survivors and Deceased Patients upon Admission to the Hospital.International journal of molecular sciences · 2022Article
- Modulation of the immune response by theFrontiers in cellular and infection microbiology · 2022Review
- Moderate blood alcohol and brain neurovulnerability: Selective depletion of calcium-independent phospholipase A2, omega-3 docosahexaenoic acid, and its synaptamide derivative as a potential harbinger of deficits in anti-inflammatory reserve.Alcoholism, clinical and experimental research · 2021Article
- Study of Resveratrol's Interaction with Planar Lipid Models: Insights into Its Location in Lipid Bilayers.Membranes · 2021Article
- Additive Effect of Resveratrol on Astrocyte Swelling Post-exposure to Ammonia, Ischemia and Trauma In Vitro.Neurochemical research · 2020Article
- Molecular Mechanism of Resveratrol's Lipid Membrane Protection.Scientific reports · 2018Article
- Macrophage migration inhibitory factor activates inflammatory responses of astrocytes through interaction with CD74 receptor.Oncotarget · 2017Article
- Peroxiredoxin 1 interacts with and blocks the redox factor APE1 from activating interleukin-8 expression.Scientific reports · 2016Article
- Phytochemicals and botanical extracts regulate NF-κB and Nrf2/ARE reporter activities in DI TNC1 astrocytes.Neurochemistry international · 2016Article
- Article
- Astrocytes regulate α-secretase-cleaved soluble amyloid precursor protein secretion in neuronal cells: Involvement of group IIA secretory phospholipase A2.Neuroscience · 2015Article
- NGF induces the expression of group IIA secretory phospholipase A2 in PC12 cells: the newly synthesized enzyme is addressed to growing neurites.Molecular neurobiology · 2014Article
- The role of Nox2-derived ROS in the development of cognitive impairment after sepsis.Journal of neuroinflammation · 2014Article
- Sutherlandia frutescens ethanol extracts inhibit oxidative stress and inflammatory responses in neurons and microglial cells.PloS one · 2014Article
- Neuroprotective roles of the P2Y(2) receptor.Purinergic signalling · 2012Review
- Regulatory effects of the JAK3/STAT1 pathway on the release of secreted phospholipase A₂-IIA in microvascular endothelial cells of the injured brain.Journal of neuroinflammation · 2012Article
- Article
- The neuroprotective effects of apocynin.Frontiers in bioscience (Elite edition) · 2012Review
- Pro-inflammatory cytokines and lipopolysaccharide induce changes in cell morphology, and upregulation of ERK1/2, iNOS and sPLA₂-IIA expression in astrocytes and microglia.Journal of neuroinflammation · 2011Article
- Phospholipases A2 and neural membrane dynamics: implications for Alzheimer's disease.Journal of neurochemistry · 2011Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Recent studies have suggested the involvement of secretory phospholipase A2-IIA (sPLA2-IIA) in neuroinflammatory diseases. Although sPLA2-IIA is transcriptionally induced through the NF-kappaB pathway by pro-inflammatory cytokines, whether this induction pathway is affected by other intracellular signaling pathways has not been investigated in detail. In this study, we demonstrated the induction of sPLA2-IIA mRNA and protein expression in astrocytes by cytokines and detected the protein in the culture medium after stimulation. We further investigated the effects of oxidative pathways and botanical antioxidants on the induction pathway and observed that IL-1beta-induced sPLA2-IIA mRNA expression in astrocytes is dependent on ERK1/2 and PI-3 kinase, but not p38 MAPK. In addition to apocynin, a known NADPH oxidase inhibitor, botanical antioxidants, such as resveratrol and epigallocatechin gallate, also inhibited IL-1beta-induced sPLA2-IIA mRNA expression. These compounds also suppressed IL-1beta-induced ERK1/2 activation and translocation of the NADPH oxidase subunit p67 phox from cytosol to membrane fraction. Taken together, these results support the involvement of reactive oxygen species from NADPH oxidase in cytokine induction of sPLA2-IIA in astrocytes and promote the use of botanical antioxidants as protective agents for inhibition of inflammatory responses in these cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.