ArticleCurrent biology : CB2009
Cytokine signaling mediates UV-induced nociceptive sensitization in Drosophila larvae.
Article in Current biology : CB, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 114 papers.
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114 citing papers in PubMed, 180 citations in OpenAlex.
- A positive feedback loop between sensory and octopaminergic neurons underlies nociceptive plasticity in Drosophila larvae.PLoS genetics · 2026Article
- The paraEuropean journal of pain (London, England) · 2026Article
- Article
- ILP4 and InR regulate paclitaxel-induced hypersensitivity differently inMolecular biology of the cell · 2026Article
- Neurexin regulates mechanical nociceptive sensitization by central inhibition inScience advances · 2025Article
- Ascending nociceptive pathways drive rapid escape and sustained avoidance in adultbioRxiv : the preprint server for biology · 2025Article
- From nociception in aneural animals to human suffering: toward a comparative biology of pain.The Journal of experimental biology · 2025Review
- Caterpillars suppress nocifensive behaviours during the quiescent 'sphinx' state.Biology letters · 2025Article
- Neural substrates of cold nociception ineLife · 2025Article
- Heat-off responses of epidermal cells sensitizebioRxiv : the preprint server for biology · 2025Article
- Article
- Nociception inCold Spring Harbor protocols · 2025Article
- RNA Sequencing Dataset ofData · 2025Article
- A nociceptor-specific RNAi screen inPeerJ · 2025Article
- Vitamin B5 is a context-dependent dietary regulator of nociception.G3 (Bethesda, Md.) · 2024Article
- Dendrite intercalation between epidermal cells tunes nociceptor sensitivity to mechanical stimuli in Drosophila larvae.PLoS genetics · 2024Article
- Cholinergic neurons trigger epithelial CaNature · 2023Article
- Dendrite intercalation between epidermal cells tunes nociceptor sensitivity to mechanical stimuli inbioRxiv : the preprint server for biology · 2023Article
- The insulin receptor regulates the persistence of mechanical nociceptive sensitization in flies and mice.Biology open · 2023Article
- Sonic Hedgehog Signaling Pathway: A Role in Pain Processing.Neurochemical research · 2023Review
54 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundHeightened nociceptive (pain) sensitivity is an adaptive response to tissue damage and serves to protect the site of injury. Multiple mediators of nociceptive sensitization have been identified in vertebrates, but the complexity of the vertebrate nervous system and tissue-repair responses has hindered identification of the precise roles of these factors.
resultsHere we establish a new model of nociceptive sensitization in Drosophila larvae, in which UV-induced tissue damage alters an aversive withdrawal behavior. We find that UV-treated larvae develop both thermal hyperalgesia, manifested as an exaggerated response to noxious thermal stimuli, and thermal allodynia, a responsiveness to subthreshold thermal stimuli that are not normally perceived as noxious. Allodynia is dependent upon a tumor necrosis factor (TNF) homolog, Eiger, released from apoptotic epidermal cells, and the TNF receptor, Wengen, expressed on nociceptive sensory neurons.
conclusionsThese results demonstrate that cytokine-mediated nociceptive sensitization is conserved across animal phyla and set the stage for a sophisticated genetic dissection of the cellular and molecular alterations responsible for development of nociceptive sensitization in sensory neurons.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.