ArticlePharmacogenomics2009
Physiogenomic analysis of the Puerto Rican population.
Article in Pharmacogenomics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01318057 (Pharmacogenetics of Warfarin in Puerto Rican Patients Using a Physiogenomics Approach.), which is not on this map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pharmacogenetics of Warfarin in Puerto Rican Patients Using a Physiogenomics Approach.
Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Do Hispanic Puerto Rican men have worse outcomes after radical prostatectomy? Results from SEARCH.Cancer medicine · 2024Article
- Differences in the Severity, Distress, Interference, and Frequency on Cancer-Related Symptoms Between Island Hispanic Puerto Ricans and Mainland Non-Hispanic Whites.Journal of immigrant and minority health · 2018Article
- Clinical Relevant Polymorphisms Affecting Clopidogrel Pharmacokinetics and Pharmacodynamics: Insights from the Puerto Rico Newborn Screening Program.International journal of environmental research and public health · 2018Article
- Impact of FTO SNPsArchives in cancer research · 2017Article
- A Novel Admixture-Based Pharmacogenetic Approach to Refine Warfarin Dosing in Caribbean Hispanics.PloS one · 2016Article
- Association of serum lipid levels and prostate cancer severity among Hispanic Puerto Rican men.Lipids in health and disease · 2015Article
- Why admixture matters in genetically-guided therapy: missed targets in the COAG and EU-PACT trials.Puerto Rico health sciences journal · 2015Article
- Pharmacogenetics of drug-metabolizing enzymes in US Hispanics.Drug metabolism and personalized therapy · 2015Review
- Pharmacogenetic association study of warfarin safety endpoints in Puerto Ricans.Puerto Rico health sciences journal · 2014Observational
- Frequencies of Functional Polymorphisms in Three Pharmacokinetic Genes of Clinical Interest within the Admixed Puerto Rican Population.Journal of pharmacogenomics & pharmacoproteomics · 2013Article
- Development of a pharmacogenetic-guided warfarin dosing algorithm for Puerto Rican patients.Pharmacogenomics · 2012Article
- Effect of NQO1 and CYP4F2 genotypes on warfarin dose requirements in Hispanic-Americans and African-Americans.Pharmacogenomics · 2012Article
- Estimating ancestral proportions in a multi-ethnic US sample: implications for studies of admixed populations.Human genomics · 2012Article
- Prediction of warfarin dose reductions in Puerto Rican patients, based on combinatorial CYP2C9 and VKORC1 genotypes.The Annals of pharmacotherapy · 2012Article
- Exposure to non-therapeutic INR in a high risk cardiovascular patient: potential hazard reduction with genotype-guided warfarin (Coumadin) dosing.Puerto Rico health sciences journal · 2010Article
- The Emerging Role of Admixture in the Pharmacogenetics of Puerto Rican Hispanics.Journal of pharmacogenomics & pharmacoproteomics · 2010Article
- CYP2C9 and VKORC1 genotypes in Puerto Ricans: A case for admixture-matching in clinical pharmacogenetic studies.Clinica chimica acta; international journal of clinical chemistry · 2010Article
- Newborn screening for hermansky-pudlak syndrome type 3 in Puerto Rico.Journal of pediatric hematology/oncology · 2010Article
- Factors Affecting the Severity of Fatigue during Radiotherapy for Prostate Cancer; an Exploratory Study.Urologic nursingArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
aimsAdmixture in the population of the island of Puerto Rico is of general interest with regards to pharmacogenetics to develop comprehensive strategies for personalized healthcare in Latin Americans. This research was aimed at determining the frequencies of SNPs in key physiological, pharmacological and biochemical genes to infer population structure and ancestry in the Puerto Rican population. MATERIALS &
methodsA noninterventional, cross-sectional, retrospective study design was implemented following a controlled, stratified-by-region, random sampling protocol. The sample was based on birthrates in each region of the island of Puerto Rico, according to the 2004 National Birth Registry. Genomic DNA samples from 100 newborns were obtained from the Puerto Rico Newborn Screening Program in dried-blood spot cards. Genotyping using a physiogenomic array was performed for 332 SNPs from 196 cardiometabolic and neuroendocrine genes. Population structure was examined using a Bayesian clustering approach as well as by allelic dissimilarity as a measure of allele sharing.
resultsThe Puerto Rican sample was found to be broadly heterogeneous. We observed three main clusters in the population, which we hypothesize to reflect the historical admixture in the Puerto Rican population from Amerindian, African and European ancestors. We present evidence for this interpretation by comparing allele frequencies for the three clusters with those for the same SNPs available from the International HapMap project for Asian, African and European populations.
conclusionOur results demonstrate that population analysis can be performed with a physiogenomic array of cardiometabolic and neuroendocrine genes to facilitate the translation of genome diversity into personalized medicine.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.