ReviewJournal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology2009
Host and viral factors influencing the pathogenesis of HIV-associated neurocognitive disorders.
Review in Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 38 citations in OpenAlex.
- Role of NLRP3 inflammasome in central nervous system diseases.Cell & bioscience · 2024Review
- HIV-1 Tat-mediated microglial inflammation involves a novel miRNA-34a-NLRC5-NFκB signaling axis.Brain, behavior, and immunity · 2019Article
- Basal ganglia shrinkage without remarkable hippocampal atrophy in chronic aviremic HIV-positive patients.Journal of neurovirology · 2018Article
- HPA-axis genes as potential risk variants for neurocognitive decline in trauma-exposed, HIV-positive females.Neuropsychiatric disease and treatment · 2018Article
- HIV-1 TAT-mediated microglial activation: role of mitochondrial dysfunction and defective mitophagy.Autophagy · 2018Article
- HIV-1-Associated Neurocognitive Disorders: Is HLA-C Binding Stability to βFrontiers in neurology · 2018Article
- Magnetic Resonance Imaging Evidence for Human Immunodeficiency Virus Effects on Central Auditory Processing: A Review.Journal of AIDS & clinical research · 2017Article
- HIV-infected microglia mediate cathepsin B-induced neurotoxicity.Journal of neurovirology · 2015Article
- HIV clades B and C are associated with reduced brain volumetrics.Journal of neurovirology · 2013Article
- Cerebral β-amyloid deposition predicts HIV-associated neurocognitive disorders in APOE ε4 carriers.AIDS (London, England) · 2012Article
- Antioxidant sestrin-2 redistribution to neuronal soma in human immunodeficiency virus-associated neurocognitive disorders.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2012Article
- Synapse loss induced by interleukin-1β requires pre- and post-synaptic mechanisms.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2012Article
- Increased cortical expression of FK506 binding protein-51 in HIV-associated neurocognitive disorders.Journal of neurovirology · 2012Article
- Interactions between human immunodeficiency virus (HIV)-1 Vpr expression and innate immunity influence neurovirulence.Retrovirology · 2011Article
- The aging of human-immunodeficiency-virus-associated neurocognitive disorders.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2009Article
- Sleep, Fatigue, and Problems With Cognitive Function in Adults Living With HIV.The Journal of the Association of Nurses in AIDS Care : JANACArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The human immunodeficiency virus (HIV) invades the central nervous system early in the course of infection and establishes a protected viral reservoir. However, neurocognitive consequences of HIV infection, known collectively as HIV-associated neurocognitive disorders (HAND), develop in only a small portion of infected patients. The precise mechanisms of pathogenesis involved in HIV-induced central nervous system injury are still not completely understood. In particular, most theories of HAND pathogenesis cannot account for either the selective vulnerability of specific neuronal populations to HIV-induced neurodegeneration or why only a subset of patients develop clinically detectable nervous system disease. Epidemiological and virological studies have identified a variety of host and viral factors that are associated with increased risk of developing HAND. Some host factors that predispose HIV-infected patients to HAND overlap with those associated with Alzheimer's disease (AD), suggesting the possibility that common pathogenic mechanisms may participate in both diseases. Here, we will review reports of host and viral factors associated with HAND and place these studies in the context of the data employed to support current theories regarding the molecular and cellular mechanisms that lead to HIV-induced neurodegeneration with additional focus on mechanisms common to AD pathogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.