ReviewApoptosis : an international journal on programmed cell death2009
Recent advances in using Drosophila to model neurodegenerative diseases.
Review in Apoptosis : an international journal on programmed cell death, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed.
- Dendrite injury triggers neuroprotection in Drosophila models of neurodegenerative disease.Scientific reports · 2024Article
- Dopamine Modulates Serotonin Innervation in theFrontiers in systems neuroscience · 2017Article
- Studying polyglutamine diseases in Drosophila.Experimental neurology · 2015Review
- The genetic basis of chronic mountain sickness.Physiology (Bethesda, Md.) · 2014Review
- Whole-genome sequencing uncovers the genetic basis of chronic mountain sickness in Andean highlanders.American journal of human genetics · 2013Article
- Whole transcriptome analysis of a reversible neurodegenerative process in Drosophila reveals potential neuroprotective genes.BMC genomics · 2012Article
- parkin-induced defects in neurophysiology and locomotion are generated by metabolic dysfunction and not oxidative stress.Human molecular genetics · 2012Article
- Healthy aging - insights from Drosophila.Frontiers in physiology · 2012Article
- Biological functions of p53 isoforms through evolution: lessons from animal and cellular models.Cell death and differentiation · 2011Review
- The Batten disease gene CLN3 is required for the response to oxidative stress.Human molecular genetics · 2011Article
- Genetic control of necrosis - another type of programmed cell death.Current opinion in cell biology · 2010Review
- Drosophila melanogaster in the study of human neurodegeneration.CNS & neurological disorders drug targets · 2010Review
- Transgenic Drosophila models of Alzheimer's disease and tauopathies.Brain structure & function · 2010Review
- Genetic modifiers of abnormal organelle biogenesis in a Drosophila model of BLOC-1 deficiency.Human molecular genetics · 2010Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
Neurodegenerative diseases are progressive disorders of the nervous system that affect the function and maintenance of specific neuronal populations. Most disease cases are sporadic with no known cause. The identification of genes associated with familial cases of these diseases has enabled the development of animal models to study disease mechanisms. The model organism Drosophila has been successfully used to study pathogenic mechanisms of a wide range of neurodegenerative diseases. Recent genetic studies in the Drosophila models have provided new insights into disease mechanisms, emphasizing the roles played by mitochondrial dynamics, RNA (including miRNA) function, protein translation, and synaptic plasticity and differentiation. It is anticipated that Drosophila models will further our understanding of mechanisms of neurodegeneration and facilitate the development of novel and rational treatments for these debilitating neurodegenerative diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.