ReviewMolecular and cellular biochemistry2009
Developmental function of Nm23/awd: a mediator of endocytosis.
Review in Molecular and cellular biochemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 21 citations in OpenAlex.
- A Unique Mode of Coenzyme A Binding to the Nucleotide Binding Pocket of Human Metastasis Suppressor NME1.International journal of molecular sciences · 2023Article
- The Impact ofInternational journal of molecular sciences · 2020Article
- The Potential Functional Roles of NME1 Histidine Kinase Activity in Neuroblastoma Pathogenesis.International journal of molecular sciences · 2020Article
- Evidence for a novel function of Awd in maintenance of genomic stability.Scientific reports · 2017Article
- Mutation of the nm23-H1 gene has a non-dominant role in colorectal adenocarcinoma.Molecular and clinical oncology · 2016Article
- Interaction between Nm23 and the tumor suppressor VHL.Naunyn-Schmiedeberg's archives of pharmacology · 2015Article
- Progress on Nme (NDP kinase/Nm23/Awd) gene family-related functions derived from animal model systems: studies on development, cardiovascular disease, and cancer metastasis exemplified.Naunyn-Schmiedeberg's archives of pharmacology · 2015Article
- Notch signaling during development requires the function of awd, the Drosophila homolog of human metastasis suppressor gene Nm23.BMC biology · 2014Article
- NDK-1, the homolog of NM23-H1/H2 regulates cell migration and apoptotic engulfment in C. elegans.PloS one · 2014Article
- Integration of the metabolic/redox state, histone gene switching, DNA replication and S-phase progression by moonlighting metabolic enzymes.Bioscience reports · 2013Article
- Article
- Toxic effect of destruxin A on abnormal wing disc-like (SLAWD) in Spodoptera litura fabricius (Lepidoptera: Noctuidae).PloS one · 2013Article
- Complex cellular functions of the von Hippel-Lindau tumor suppressor gene: insights from model organisms.Oncogene · 2012Review
- NME genes in epithelial morphogenesis.Naunyn-Schmiedeberg's archives of pharmacology · 2011Review
- Sponge non-metastatic Group I Nme gene/protein - structure and function is conserved from sponges to humans.BMC evolutionary biology · 2011Article
- Nucleoside diphosphate kinase B knock-out mice have impaired activation of the K+ channel KCa3.1, resulting in defective T cell activation.The Journal of biological chemistry · 2010Article
- Nucleoside diphosphate kinase (NDPK, NM23, AWD): recent regulatory advances in endocytosis, metastasis, psoriasis, insulin release, fetal erythroid lineage and heart failure; translational medicine exemplified.Molecular and cellular biochemistry · 2009Article
- The Drosophila metastasis suppressor gene Nm23 homolog, awd, regulates epithelial integrity during oogenesis.Molecular and cellular biology · 2009Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The metastasis suppressor gene Nm23 is highly conserved from yeast to human, implicating a critical developmental function. Studies in cultured mammalian cells have identified several potential functions, but many have not been directly verified in vivo. Here, we summarize the studies on the Drosophila homolog of the Nm23 gene, named a bnormal w ing d iscs (awd), which shares 78% amino acid identity with the human Nm23-H1 and H2 isoforms. These studies confirmed that awd gene encodes a nucleoside diphosphate kinase, and provided strong evidence of a role for awd in regulating cell differentiation and motility via regulation of growth factor receptor signaling. The latter function is mainly mediated by control of endocytosis. This review provides a historical account of the discovery and subsequent analyses of the awd gene. We will also discuss the possible molecular function of the Awd protein that underlies the endocytic function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.