ArticleHuman genetics2009
Association of three-gene interaction among MTHFR, ALOX5AP and NOTCH3 with thrombotic stroke: a multicenter case-control study.
Article in Human genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Association ofMedicina (Kaunas, Lithuania) · 2019Pooled it
- Pooled it
- Coagulation Factor XIII Val34Leu Polymorphism in the Prediction of Premature Cardiovascular Events-The Results of Two Meta-Analyses.Journal of clinical medicine · 2022Article
- Association of laboratory parameters and genetic polymorphisms with ischemic stroke in Chinese Han population.Experimental and therapeutic medicine · 2021Article
- A Patient with Combined CADASIL and MTHFR Homozygosity.Case reports in neurological medicine · 2020Article
- The Role of Polymorphism GenOpen access Macedonian journal of medical sciences · 2019Article
- DCDC2 gene polymorphisms are associated with developmental dyslexia in Chinese Uyghur children.Neural regeneration research · 2017Article
- Interaction Between CYP4F2 rs2108622 and CPY4A11 rs9333025 Variants Is Significantly Correlated with Susceptibility to Ischemic Stroke and 20-Hydroxyeicosatetraenoic Acid Level.Genetic testing and molecular biomarkers · 2016Article
- A roadmap to multifactor dimensionality reduction methods.Briefings in bioinformatics · 2016Review
- Association ofExperimental and therapeutic medicine · 2016Article
- NOTCH3 gene polymorphism is associated with the prognosis of gliomas in Chinese patients.Medicine · 2015Article
- A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients.Breast cancer research : BCR · 2013Article
- Novel association of a PROC variant with ischemic stroke in a Chinese Han population.Human genetics · 2013Article
- Increased risk of stroke in oral contraceptive users carried replicated genetic variants: a population-based case-control study in China.Human genetics · 2012Article
- Assessing gene-gene interactions in pharmacogenomics.Molecular diagnosis & therapy · 2012Review
- Association of ALOX5AP with ischemic stroke in eastern Chinese.World journal of emergency medicine · 2012Article
- Variants in the inflammatory IL6 and MPO genes modulate stroke susceptibility through main effects and gene-gene interactions.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2011Article
- Neural networks for modeling gene-gene interactions in association studies.BMC genetics · 2009Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stroke is a common complex trait and does not follow Mendelian pattern of inheritance. Gene-gene or gene-environment interactions may be responsible for the complex trait. How the interactions contribute to stroke is still under research. This study aimed to explore the association between gene-gene interactions and stroke in Chinese in a large case-control study. Nearly 4,000 participants were recruited from seven clinical centers. Eight variants in five candidate genes were examined for stroke risk. Gene-gene interactions were explored by using Generalized Multifactor Dimensionality Reduction (GMDR). A significant gene-gene interaction was found by GMDR. The best model including MTHFR C677T, ALOX5AP T2354A and NOTCH3 C381T scored 10 for Cross-Validation Consistency and 9 for Sign Test (P = 0.0107). The individuals with combination of MTHFR 677TT, ALOX5AP 2354AA and NOTCH3 381TT/TC had a significantly higher risk of thrombotic stroke (OR 3.165, 95% CI 1.461-6.858, P = 0.003). Our results show that combination of these alleles conferred higher risk for stroke than single risk allele. The gene-gene interaction may serve as a novel area for stroke research. The three-locus combination may change the susceptibility of particular subjects to the disease.
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