ReviewCell adhesion & migration
Integrin-mediated regulation of neurovascular development, physiology and disease.
Review in Cell adhesion & migration. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 34 citations in OpenAlex.
- Cell-to-Cell Signaling Networks at the Blood-Brain Barrier in Health and Disease.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- The potential and therapeutic advances of the integrin family in neurological disorders.Neural regeneration research · 2026Article
- Blood-brain barrier and blood-tumoral barrier formation in glioblastoma: endothelial cells and glioblastoma stem cells at the immune-brain crossroad.Fluids and barriers of the CNS · 2026Review
- GlialeLife · 2026Article
- The Effect of TGF-β1 Reduced Functionality on the Expression of Selected Synaptic Proteins and Electrophysiological Parameters: Implications of Changes Observed in Acute Hepatic Encephalopathy.International journal of molecular sciences · 2022Article
- Biomaterials for Bioprinting Microvasculature.Chemical reviews · 2020Review
- Human neural stem cell-induced endothelial morphogenesis requires autocrine/paracrine and juxtacrine signaling.Scientific reports · 2016Article
- Neuropilin 1 balances β8 integrin-activated TGFβ signaling to control sprouting angiogenesis in the brain.Development (Cambridge, England) · 2015Article
- Vascularisation of the central nervous system.Mechanisms of development · 2015Review
- Protein tyrosine phosphatase-PEST and β8 integrin regulate spatiotemporal patterns of RhoGDI1 activation in migrating cells.Molecular and cellular biology · 2015Article
- Effect of mixed transplantation of autologous and allogeneic microskin grafts on wound healing in a rat model of acute skin defect.PloS one · 2014Article
- ALS and oxidative stress: the neurovascular scenario.Oxidative medicine and cellular longevity · 2013Review
- Astroglial integrins in the development and regulation of neurovascular units.Pain research and treatment · 2012Article
- Overview: studying integrins in vivo.Methods in molecular biology (Clifton, N.J.) · 2012Review
- Extracellular matrix and matrix receptors in blood-brain barrier formation and stroke.Developmental neurobiology · 2011Review
- TGF-β signaling in endothelial cells, but not neuroepithelial cells, is essential for cerebral vascular development.Laboratory investigation; a journal of technical methods and pathology · 2011Article
- αV integrins in angiogenesis and cancer.Cold Spring Harbor perspectives in medicine · 2011Review
- Angiogenic sprouting into neural tissue requires Gpr124, an orphan G protein-coupled receptor.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- A mosaic mouse model of astrocytoma identifies alphavbeta8 integrin as a negative regulator of tumor angiogenesis.Oncogene · 2010Article
- Brain endothelial cell death: modes, signaling pathways, and relevance to neural development, homeostasis, and disease.Molecular neurobiology · 2010Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The mammalian central nervous system (CNS) is comprised of billions of neurons and glia that are intertwined with an elaborate network of blood vessels. These various neural and vascular cell types actively converse with one another to form integrated, multifunctional complexes, termed neurovascular units. Cell-cell communication within neurovascular units promotes normal CNS development and homeostasis, and abnormal regulation of these events leads to a variety of debilitating CNS diseases. This review will summarize (1) cellular and molecular mechanisms that regulate physiological assembly and maintenance of neurovascular units; and (2) signaling events that induce pathological alterations in neurovascular unit formation and function. An emphasis will be placed on neural-vascular cell adhesion events mediated by integrins and their extracellular matrix (ECM) ligands. I will highlight the role of a specific adhesion and signaling axis involving alphavbeta8 integrin, latent transforming growth factor beta's (TGFbeta's), and canonical TGFbeta receptors. Possible functional links between components of this axis and other signal transduction cascades implicated in neurovascular development and disease will be discussed. Comprehensively understanding the pathways that regulate bidirectional neural-vascular cell contact and communication will provide new insights into the mechanisms of neurovascular unit development, physiology and disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.