ArticleJournal of applied physiology (Bethesda, Md. : 1985)2009
Transpulmonary passage of 99mTc macroaggregated albumin in healthy humans at rest and during maximal exercise.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Decreased arterial PO2, not O2 content, increases blood flow through intrapulmonary arteriovenous anastomoses at rest.The Journal of physiology · 2016Trial
- Hypoxia and exercise increase the transpulmonary passage of 99mTc-labeled albumin particles in humans.PloS one · 2014Trial
- Evaluation of intrapulmonary arteriovenous anastomoses before and after oxygen supplementation, using transthoracic agitated saline contrast echocardiography in rescued Korean raccoon dogs.Frontiers in veterinary science · 2024Article
- The Pulmonary Vasculature.Seminars in respiratory and critical care medicine · 2023Review
- Lung functional imaging.Breathe (Sheffield, England) · 2023Article
- Early Endothelial Signaling Transduction in Developing Lung Edema.Life (Basel, Switzerland) · 2023Review
- A century of exercise physiology: lung fluid balance during and following exercise.European journal of applied physiology · 2023Review
- Minute ventilation/carbon dioxide production in congenital heart disease.European respiratory review : an official journal of the European Respiratory Society · 2021Review
- Intra-pulmonary arteriovenous anastomoses and pulmonary gas exchange: evaluation by microspheres, contrast echocardiography and inert gas elimination.The Journal of physiology · 2019Article
- Beta Adrenergic Regulation of Intrapulmonary Arteriovenous Anastomoses in Intact Rat and Isolated Rat Lungs.Frontiers in physiology · 2017Article
- Arterio-venous anastomoses in isolated, perfused rat lungs.Physiological reports · 2016Article
- Arterial to end-tidal Pco2 difference during exercise in normoxia and severe acute hypoxia: importance of blood temperature correction.Physiological reports · 2015Article
- Intrapulmonary arteriovenous anastomoses in humans--response to exercise and the environment.The Journal of physiology · 2015Review
- Hypoxia, not pulmonary vascular pressure, induces blood flow through intrapulmonary arteriovenous anastomoses.The Journal of physiology · 2015Article
- Transient intrapulmonary shunting in a patient treated with β₂-adrenergic agonists for status asthmaticus.Pediatrics · 2014Article
- Pulmonary gas exchange and acid-base balance during exercise.Comprehensive Physiology · 2013Review
- The effects of dobutamine and dopamine on intrapulmonary shunt and gas exchange in healthy humans.Journal of applied physiology (Bethesda, Md. : 1985) · 2012Article
- Hypoxia recruits intrapulmonary arteriovenous pathways in intact rats but not isolated rat lungs.Journal of applied physiology (Bethesda, Md. : 1985) · 2012Article
- Pulmonary pathways and mechanisms regulating transpulmonary shunting into the general circulation: an update.Injury · 2010Review
- Threshold size for optimal passive pulmonary targeting and retention of rigid microparticles in rats.Journal of controlled release : official journal of the Controlled Release Society · 2010Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
We have demonstrated that 50-mum-diameter arteriovenous pathways exist in isolated, healthy human and baboon lungs, ventilated and perfused under physiological pressures. These findings have been confirmed and extended by demonstrating the passage of 25-microm microspheres through the lungs of exercising dogs, but not at rest. Determination of blood flow through these large-diameter intrapulmonary arteriovenous pathways would be an important first step to establish a physiological role for these vessels. Currently, we sought to estimate blood flow through these arteriovenous pathways using technetium-99m ((99m)Tc)-labeled macroaggregated albumin (MAA) in healthy humans at rest and during maximal treadmill exercise. We hypothesized that the percentage of (99m)Tc MAA able to traverse the pulmonary circulation (%transpulmonary passage) would increase during exercise. Seven male subjects without patent foramen ovale were injected with (99m)Tc MAA at rest on 1 day and during maximal treadmill exercise on a separate day (>6 days). Within 5 min after injection, subjects began whole body imaging in the supine position. Six of the seven subjects showed an increase in transpulmonary passage of MAA with maximal exercise. Using two separate analysis methods, percent transpulmonary passage significantly increased with exercise from baseline to absolute values of 1.2 +/- 0.8% (P = 0.008) and 1.3 +/- 1.0% (P = 0.016), respectively (means +/- SD; paired t-test). We conclude that MAA may be traversing the pulmonary circulation via large-diameter intrapulmonary arteriovenous conduits in healthy humans during exercise. Recruitment of these pathways may divert blood flow away from pulmonary capillaries during exercise and compromise the lung's function as a biological filter.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.