ArticleJournal of neurology, neurosurgery, and psychiatry2009
Twin pairs discordant for neuropathologically confirmed Lewy body dementia.
Article in Journal of neurology, neurosurgery, and psychiatry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 25 citations in OpenAlex.
- Genetic Architecture and Molecular, Imaging and Prodromic Markers in Dementia with Lewy Bodies: State of the Art, Opportunities and Challenges.International journal of molecular sciences · 2021Review
- Molecular Genetics of Neurodegenerative Dementias.Cold Spring Harbor perspectives in biology · 2017Review
- Genetics and underlying pathology of dementia.Neuropsychology review · 2015Review
- Neuropathologic assessment of dementia markers in identical and fraternal twins.Brain pathology (Zurich, Switzerland) · 2014Article
- The LEARn model: an epigenetic explanation for idiopathic neurobiological diseases.Molecular psychiatry · 2009Article
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
aimLittle is known about the concordance rate in twins for dementia with Lewy bodies (DLB). The rate of agreement between clinical and pathological diagnoses for DLB is typically low, necessitating confirmation of the diagnosis neuropathologically.
methodsParticipants were 17 twin pairs enrolled in the Duke Twins Study of Memory in Aging in which at least one member of the pair had an autopsy confirmed diagnosis of DLB, Alzheimer's disease (AD) with Lewy bodies or frontotemporal dementia with Lewy bodies. The characteristics of those with dementia were assessed and rates of concordance for pathological confirmed dementia were examined.
resultsFour monozygotic twin pairs had a proband with neuropathologically confirmed pure DLB; all remained discordant for dementia for periods up to 16 years or more. Five of 13 pairs in which the proband had AD plus DLB were concordant for dementia but only one pair was concordant for AD plus DLB, while the co-twins in the other four pairs had other types of dementia.
conclusionsThe present study indicates that even among twins, a diagnosis of DLB in one twin does not predict the same diagnosis in the other twin. Neuropathological discordance in type of dementia among monozygotic pairs hints at environmental or epigenetic factors playing a role in Lewy body pathology.
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