ArticleMolecular endocrinology (Baltimore, Md.)2009
ALU repeats in promoters are position-dependent co-response elements (coRE) that enhance or repress transcription by dimeric and monomeric progesterone receptors.
Article in Molecular endocrinology (Baltimore, Md.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 43 citations in OpenAlex.
- LINE1-mediated epigenetic repression of androgen receptor transcription causes androgen insensitivity syndrome.Scientific reports · 2024Article
- A molecular toolbox to study progesterone receptor signaling.Journal of mammary gland biology and neoplasia · 2023Article
- B2 SINE RNA as a novel regulator of glucocorticoid receptor transcriptional activity.Neurobiology of stress · 2023Article
- The Effect of Glucocorticoids onJournal of the ASEAN Federation of Endocrine Societies · 2023Article
- Utilizing an Endogenous Progesterone Receptor Reporter Gene for Drug Screening and Mechanistic Study in Endometrial Cancer.Cancers · 2022Article
- The Role of Transposable Elements in Sexual Development.Frontiers in behavioral neuroscience · 2022Review
- Corticosterone dynamically regulates retrotransposable element expression in the rat hippocampus and C6 cells.Neurobiology of stress · 2021Article
- SNP located in anThe British journal of ophthalmology · 2019Article
- SUMOylation Regulates Transcription by the Progesterone Receptor A Isoform in a Target Gene Selective Manner.Diseases (Basel, Switzerland) · 2018Article
- Structural variants caused byProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Stress and the dynamic genome: Steroids, epigenetics, and the transposome.Proceedings of the National Academy of Sciences of the United States of America · 2015Review
- Article
- Control of endothelin-a receptor expression by progesterone is enhanced by synergy with Gata2.Molecular endocrinology (Baltimore, Md.) · 2013Article
- Estrogen switches pure mucinous breast cancer to invasive lobular carcinoma with mucinous features.Breast cancer research and treatment · 2013Article
- Progesterone receptors, their isoforms and progesterone regulated transcription.Molecular and cellular endocrinology · 2012Review
- Glucocorticoid receptor-promoter interactions: energetic dissection suggests a framework for the specificity of steroid receptor-mediated gene regulation.Biochemistry · 2012Article
- Control of progesterone receptor transcriptional synergy by SUMOylation and deSUMOylation.BMC molecular biology · 2012Article
- Heat shock factor binding in Alu repeats expands its involvement in stress through an antisense mechanism.Genome biology · 2011Article
- Nuclear receptor HNF4α binding sequences are widespread in Alu repeats.BMC genomics · 2011Article
- The rules of DNA recognition by the androgen receptor.Molecular endocrinology (Baltimore, Md.) · 2010Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
We have conducted an in silico analysis of progesterone response elements (PRE) in progesterone receptor (PR) up-regulated promoters. Imperfect inverted repeats, direct repeats, and half-site PRE are widespread, not only in PR-regulated, but also in non-PR-regulated and random promoters. Few resemble the commonly used palindromic PRE with three nucleotide (nt) spacers. We speculated that PRE may be necessary but insufficient to control endogenous PR-dependent transcription. A search for PRE partners identified a highly conserved 234-nt sequence invariably located within 1-2 kb of transcription start sites. It resembles ALU repeats and contains binding sites for 11 transcription factors. The 234-nt sequence of the PR-regulated 8-oxoguanine DNA glycosylase promoter was cloned in the forward or reverse orientation in front of zero, one, or two inverted repeat PRE, and one or tandem PRE half-sites, driving luciferase. Under these conditions the 234-nt sequence functions as a co-response element (coRE). From the PRE or tandem half-sites, the reverse coRE is a strong activator of PR and glucocorticoid receptor-dependent transcription. The forward coRE is a powerful repressor. The prevalence of PRE half-sites in natural promoters suggested that PR monomers regulate transcription. Indeed, dimerization-domain mutant PR monomers were stronger transactivators than wild-type PR on PRE or tandem half-sites. This was repressed by the forward coRE. We propose that in natural promoters the coRE functions as a composite response element with imperfect PRE and half-sites to present variable, orientation-dependent transcription factors for interaction with nearby PR.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.