Evidence map›Paper›PMID 19372214›Full record

ArticleAmerican journal of epidemiology2009

Self-reported vitamin supplementation in early pregnancy and risk of miscarriage.

Reem Hasan, Andrew F Olshan, Amy H Herring, David A Savitz, Anna Maria Siega-Riz, Katherine E Hartmann

Abstract read
In one paragraph

Article in American journal of epidemiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Vitamin supplementation for preventing miscarriage.The Cochrane database of systematic reviews · 2016
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Increasing the Chances of Natural Conception: Opinion Statement from the the Brazilian Federation of Gynecology and Obstetrics Associations - FEBRASGO - Committee of Gynecological Endocrinology.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2019
    Article
  7. Diet and fertility: a review.American journal of obstetrics and gynecology · 2018
    Review
  8. Article
  9. Observational
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  11. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Reem HasanDepartment of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7435, USA. reem_hasan@med.unc.edu
Andrew F Olshan
Amy H Herring
David A Savitz
Anna Maria Siega-Riz
Katherine E Hartmann

Funding

UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Melissa A. Troester · 2001 to 2026
$36.3M
Carolina Population CenterR24HD050924 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MORGAN, SAMUEL PHILIP · 2005 to 2014
$10.0M
Consequences and Course of Uterine Fibroids in PregnancyR01HD043883 · NICHD · VANDERBILT UNIVERSITY · PI HARTMANN, KATHERINE E · 2004 to 2008
$3.1M
Non-steroidal anti-inflammatory use and miscarriageR01HD049675 · NICHD · VANDERBILT UNIVERSITY · PI HARTMANN, KATHERINE E · 2006 to 2010
$2.6M
NICHD NIH HHS 5R01HD043883NICHD NIH HHS 5R01HD049675NICHD NIH HHS R01 HD043883NICHD NIH HHS R01 HD049675NICHD NIH HHS R24 HD050924NIEHS NIH HHS P30 ES010126NIEHS NIH HHS P30ES10126
6 · The paper itself

Abstract

Miscarriage is a common and poorly understood adverse pregnancy outcome. In this study, the authors sought to evaluate the relation between self-reported use of prenatal vitamins in early pregnancy and the risk of miscarriage. Between 2000 and 2008, 4,752 US women were prospectively enrolled in Right From the Start. Information about vitamin use was obtained from a first-trimester interview. Discrete-time hazard models were used, candidate confounders were assessed, and the following variables were included in the model: study site, maternal age, gravidity, marital status, education, race/ethnicity, smoking, and use of progesterone in early pregnancy. Approximately 95% of participants reported use of vitamins during early pregnancy. A total of 524 women had a miscarriage. In the final adjusted model, any use of vitamins during pregnancy was associated with decreased odds of miscarriage (odds ratio = 0.43, 95% confidence interval: 0.30, 0.60) in comparison with no exposure. These results should be viewed in the context of a potentially preventive biologic mechanism mitigated by possible confounding by healthy behaviors and practices that are also associated with vitamin supplement use during pregnancy.

Indexed as

Abortion, SpontaneousAdultConfounding Factors, EpidemiologicFemaleGestational AgeHumansPregnancyPregnancy OutcomePregnancy Trimester, FirstProportional Hazards ModelsProspective StudiesRiskUltrasonography, PrenatalVitaminsVitamins

Identifiers

PMID19372214
PMCPMC2727248

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.