ReviewEndocrinology2009
Minireview: Gut peptides: targets for antiobesity drug development?
Review in Endocrinology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01008371 (CCK-dysregulation), which is not on this map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
CCK-dysregulation: Mechanisms of Abnormal Food Regulation and Obesity
Who cites it
22 citing papers in PubMed.
- Novel Pharmaceuticals in Appetite Regulation: Exploring emerging gut peptides and their pharmacological prospects.Pharmacology research & perspectives · 2024Review
- Effects of Bioactive Peptides from Atlantic Salmon Processing By-Products on Oxyntopeptic and Enteroendocrine Cells of the Gastric Mucosa of European Seabass and Gilthead Seabream.Animals : an open access journal from MDPI · 2023Article
- Alterations in circadian and meal-induced gut peptide levels in lean and obese rats.Experimental biology and medicine (Maywood, N.J.) · 2017Article
- Marine Peptides as Potential Agents for the Management of Type 2 Diabetes Mellitus-A Prospect.Marine drugs · 2017Review
- From Belly to Brain: Targeting the Ghrelin Receptor in Appetite and Food Intake Regulation.International journal of molecular sciences · 2017Review
- Protein Digestion-Derived Peptides and the Peripheral Regulation of Food Intake.Frontiers in endocrinology · 2017Review
- Small lipidated anti-obesity compounds derived from neuromedin U.European journal of medicinal chemistry · 2015Article
- Reduced plasma level of diazepam-binding inhibitor (DBI) in patients with morbid obesity.Endocrine · 2015Article
- The role of hypothalamic estrogen receptors in metabolic regulation.Frontiers in neuroendocrinology · 2014Review
- Gut-Brain Endocrine Axes in Weight Regulation and Obesity Pharmacotherapy.Journal of clinical medicine · 2014Review
- New advances in models and strategies for developing anti-obesity drugs.Expert opinion on drug discovery · 2013Review
- Obesity pharmacotherapy: what is next?Molecular aspects of medicine · 2013Review
- Insulin-Producing Cells in the Drosophila Brain also Express Satiety-Inducing Cholecystokinin-Like Peptide, Drosulfakinin.Frontiers in endocrinology · 2012Article
- Current and future drug targets in weight management.Pharmaceutical research · 2011Review
- Interaction between gastric and upper small intestinal hormones in the regulation of hunger and satiety: ghrelin and cholecystokinin take the central stage.Current protein & peptide science · 2011Review
- Current and emerging therapies for the management of functional gastrointestinal disorders.Therapeutic advances in chronic disease · 2011Article
- Regulation of appetite to treat obesity.Expert review of clinical pharmacology · 2011Review
- Current trends in targeting the hormonal regulation of appetite and energy balance to treat obesity.Expert review of endocrinology & metabolism · 2010Article
- Sensitivity to the satiating effects of exendin 4 is decreased in obesity-prone Osborne-Mendel rats compared to obesity-resistant S5B/Pl rats.International journal of obesity (2005) · 2010Article
- Sizing up pharmacotherapy for obesity.Clinical and translational science · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Gut peptides play multiple roles in the controls of gastrointestinal function and in the initiation and termination of meals. Plasma levels of these peptides are differentially affected by the presence of nutrients in the digestive tract, and the patterns of peptide release are consistent with both their feeding stimulatory and inhibitory actions. A number of these peptide systems have been investigated as potential targets for antiobesity drug development. Progress has been made in developing long-acting peptide analogs and, in some cases, nonpeptide agonists and antagonists. Whether any individual approach will have significant long-term efficacy remains to be demonstrated. Approaches that target multiple systems may hold the most promise.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.