ArticleMicrobiology (Reading, England)2009
Interplay of cellular cAMP levels, {sigma}S activity and oxidative stress resistance in Escherichia coli.
Article in Microbiology (Reading, England), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 66 citations in OpenAlex.
- Synergistic interactions between glycogen and trehalose mediate adaptation to the stationary phase inJournal of bacteriology · 2026Article
- Effect of Thioredoxin Tag, Oxidizing Environment, and Temperature on the Global Metabolome of E. Coli Strains.Applied biochemistry and biotechnology · 2026Article
- Common food preservatives induce an oxidative stress response inMicrobiology (Reading, England) · 2025Article
- cAMP-CRP-activatedFrontiers in microbiology · 2025Article
- Exploiting cAMP signaling in Mycobacterium tuberculosis for drug discovery.Trends in microbiology · 2024Review
- The role of metals in hypothiocyanite resistance inJournal of bacteriology · 2024Article
- CRP and IHF act as host regulators in Royal Jelly's antibacterial activity.Scientific reports · 2024Article
- The role of metals in hypothiocyanite resistance inbioRxiv : the preprint server for biology · 2024Article
- Mutations upstream fromJournal of bacteriology · 2024Article
- DegS protease regulates antioxidant capacity and adaptability to oxidative stress environment inFrontiers in cellular and infection microbiology · 2023Article
- A broadly applicable, stress-mediated bacterial death pathway regulated by the phosphotransferase system (PTS) and the cAMP-Crp cascade.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Dps Is a Universally Conserved Dual-Action DNA-Binding and Ferritin Protein.Journal of bacteriology · 2022Review
- What Flips the Switch? Signals and Stress Regulating Extraintestinal PathogenicMicroorganisms · 2021Review
- Upregulation of PBP1B and LpoB inAntimicrobial agents and chemotherapy · 2019Article
- Assessing the benefits of horizontal gene transfer by laboratory evolution and genome sequencing.BMC evolutionary biology · 2018Article
- Article
- RpoS-independent evolution reveals the importance of attenuated cAMP/CRP regulation in high hydrostatic pressure resistance acquisition in E. coli.Scientific reports · 2017Article
- Cyclic AMP Receptor Protein Acts as a Transcription Regulator in Response to Stresses in Deinococcus radiodurans.PloS one · 2016Article
- Article
- The non-catalytic "cap domain" of a mycobacterial metallophosphoesterase regulates its expression and localization in the cell.The Journal of biological chemistry · 2014Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Hypochlorous acid (HOCl), the active ingredient of household bleach, functions as a powerful antimicrobial that is used not only in numerous industrial applications but also in mammalian host defence. Here we show that multicopy expression of cpdA, encoding the cAMP phosphodiesterase, leads to a dramatically increased resistance of Escherichia coli to HOCl stress as well as to the unrelated hydrogen peroxide (H(2)O(2)) stress. This general oxidative stress resistance is apparently caused by the CpdA-mediated decrease in cellular cAMP levels, which leads to the partial inactivation of the global transcriptional regulator cAMP receptor protein (CRP). Downregulation of CRP in turn causes the derepression of rpoS, encoding the alternative sigma factor sigma(S), which activates the general stress response in E. coli. We found that these highly oxidative stress-resistant cells have a substantially increased capacity to combat HOCl-mediated insults and to degrade reactive oxygen species. Mutational analysis revealed that the DNA-protecting protein Dps, the catalase KatE, and the exonuclease III XthA play the predominant roles in conferring the high resistance of rpoS-overexpressing strains towards HOCl and H(2)O(2) stress. Our results demonstrate the close regulatory interplay between cellular cAMP levels, sigma(S) activity and oxidative stress resistance in E. coli.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.