ArticleMolecular and cellular neurosciences2009
Phr1 regulates retinogeniculate targeting independent of activity and ephrin-A signalling.
Article in Molecular and cellular neurosciences, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 23 citations in OpenAlex.
- Article
- Molecular guidance cues in the development of visual pathway.Protein & cell · 2018Review
- The PHR proteins: intracellular signaling hubs in neuronal development and axon degeneration.Neural development · 2016Review
- A novel mouse model of tuberous sclerosis complex (TSC): eye-specific Tsc1-ablation disrupts visual-pathway development.Disease models & mechanisms · 2015Article
- Functional assembly of accessory optic system circuitry critical for compensatory eye movements.Neuron · 2015Article
- Identification of a peptide inhibitor of the RPM-1 · FSN-1 ubiquitin ligase complex.The Journal of biological chemistry · 2014Article
- RPM-1 is localized to distinct subcellular compartments and regulates axon length in GABAergic motor neurons.Neural development · 2014Article
- RPM-1 uses both ubiquitin ligase and phosphatase-based mechanisms to regulate DLK-1 during neuronal development.PLoS genetics · 2014Article
- Loss of the spectraplakin short stop activates the DLK injury response pathway in Drosophila.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- The role of ubiquitin-mediated pathways in regulating synaptic development, axonal degeneration and regeneration: insights from fly and worm.The Journal of physiology · 2013Review
- The Phr1 ubiquitin ligase promotes injury-induced axon self-destruction.Cell reports · 2013Article
- Breaking it down: the ubiquitin proteasome system in neuronal morphogenesis.Neural plasticity · 2013Review
- Identification of potential mediators of retinotopic mapping: a comparative proteomic analysis of optic nerve from WT and Phr1 retinal knockout mice.Journal of proteome research · 2012Article
- Ten-m3 is required for the development of topography in the ipsilateral retinocollicular pathway.PloS one · 2012Article
- Highwire regulates guidance of sister axons in the Drosophila mushroom body.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Drosophila Rae1 controls the abundance of the ubiquitin ligase Highwire in post-mitotic neurons.Nature neuroscience · 2011Article
- Zic2 regulates the expression of Sert to modulate eye-specific refinement at the visual targets.The EMBO journal · 2010Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Proper functioning of the mammalian visual system requires that connections between the eyes and their central targets develop precisely. At birth, axons from the two eyes project to broad, overlapping regions of the dorsal-lateral geniculate nucleus (dLGN). In the adult, retinal axons segregate into distinct monocular regions at stereotyped locations within the dLGN. This process is driven by both molecular cues and activity-dependent synaptic competition. Here we demonstrate that Phr1, an evolutionarily conserved regulator of synapse formation and axon guidance, defines a novel molecular pathway required for proper localization of retinogeniculate projections. Following conditional excision of Phr1 in the retina, eye-specific domains within the dLGN are severely disturbed, despite normal spontaneous retinal wave activity and monocular segregation. Although layer placement is dramatically altered, Phr1 mutant retinal axons respond to ephrin-A in vitro. These findings indicate that Phr1 is a key presynaptic regulator of retinogeniculate layer placement independent of activity, segregation, or ephrin-A signaling.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.