ArticleExperimental cell research2009
The cytoskeletal scaffold Shank3 is recruited to pathogen-induced actin rearrangements.
Article in Experimental cell research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- The enteric nervous system deficits in autism spectrum disorder.Frontiers in neuroscience · 2023Review
- Identification of ultra-rare genetic variants in pediatric acute onset neuropsychiatric syndrome (PANS) by exome and whole genome sequencing.Scientific reports · 2022Article
- Altered Intestinal Morphology and Microbiota Composition in the Autism Spectrum Disorders Associated SHANK3 Mouse Model.International journal of molecular sciences · 2019Article
- Intestinal dysmotility in a zebrafish (Molecular autism · 2019Article
- Characterization and transplantation of enteric neural crest cells from human induced pluripotent stem cells.Molecular psychiatry · 2018Article
- The utility of patient specific induced pluripotent stem cells for the modelling of Autistic Spectrum Disorders.Psychopharmacology · 2014Review
- Molecular handoffs in nitrergic neurotransmission.Frontiers in medicine · 2014Review
- Studying autism in rodent models: reconciling endophenotypes with comorbidities.Frontiers in human neuroscience · 2013Article
- Salmonella - at home in the host cell.Frontiers in microbiology · 2011Article
- Calpain mediates epithelial cell microvillar effacement by enterohemorrhagic Escherichia coli.Frontiers in microbiology · 2011Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
The common gastrointestinal pathogens enteropathogenic Escherichia coli (EPEC) and Salmonella typhimurium both reorganize the gut epithelial cell actin cytoskeleton to mediate pathogenesis, utilizing mimicry of the host signaling apparatus. The PDZ domain-containing protein Shank3, is a large cytoskeletal scaffold protein with known functions in neuronal morphology and synaptic signaling, and is also capable of acting as a scaffolding adaptor during Ret tyrosine kinase signaling in epithelial cells. Using immunofluorescent and functional RNA-interference approaches we show that Shank3 is present in both EPEC- and S. typhimurium-induced actin rearrangements and is required for optimal EPEC pedestal formation. We propose that Shank3 is one of a number of host synaptic proteins likely to play key roles in bacteria-host interactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.