Evidence map›Paper›PMID 19371718›Full record

ReviewBiochimica et biophysica acta2009

Cardiolipin membrane domains in prokaryotes and eukaryotes.

Eugenia Mileykovskaya, William Dowhan

Abstract readReview
In one paragraph

Review in Biochimica et biophysica acta, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 190 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
190citing papers in PubMed, 1 pooled it
8.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

190 citing papers in PubMed, 1 synthesis or guideline pooled it, 389 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Mitochondrial membrane remodeling in stress adaptation: Lipid control of organelle quality.Protein science : a publication of the Protein Society · 2026
    Review
  4. New insights into the structure-based mechanism ofApplied and environmental microbiology · 2026
    Article
  5. Lipid landscaping of the bacterial cell surface.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. The impact of sublethal antimicrobial blue light on lipidomic changes ofFrontiers in cellular and infection microbiology · 2025
    Article
  16. Review
  17. Review
  18. Review
  19. Article
  20. Article

130 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Eugenia MileykovskayaDepartment of Biochemistry and Molecular Biology, University of Texas Medical School, Houston, TX 77030, USA. Eugenia.Mileykovskaya@uth.tmc.edu
William Dowhan
The University of Texas at Austin · USThe University of Texas Health Science Center at Houston · US

Funding

Structure and Function in Membrane ProteinsR37GM020478 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI DOWHAN, WILLIAM · 2005 to 2015
$5.4M
PHOSPHOLIPIDS AND MITOCHONDRIAL FUNCTIONR01GM056389 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI DOWHAN, WILLIAM · 1998 to 2011
$4.2M
STRUCTURE/FUNCTION OF MEMBRANE PROTEINSR01GM020478 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI DOWHAN, WILLIAM · 1985 to 2004
$1.8M
DNA CYTOSINE C5 METHYLTRANSFERASER01GM056289 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI REICH, NORBERT O. · 1997 to 2000
$142k
KARYOPHERIN X, A NOVEL TRANSPORT RECEPTORF32GM020478 · NIGMS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI PLAFKER, SCOTT M · 2000 to 2000
$38k
NIGMS NIH HHS F32 GM020478NIGMS NIH HHS GM020478NIGMS NIH HHS GM056289NIGMS NIH HHS R01 GM020478NIGMS NIH HHS R01 GM056389NIGMS NIH HHS R37 GM020478
6 · The paper itself

Abstract

Cardiolipin (CL) plays a key role in dynamic organization of bacterial and mitochondrial membranes. CL forms membrane domains in bacterial cells, and these domains appear to participate in binding and functional regulation of multi-protein complexes involved in diverse cellular functions including cell division, energy metabolism, and membrane transport. Visualization of CL domains in bacterial cells by the fluorescent dye 10-N-nonyl acridine orange is critically reviewed. Possible mechanisms proposed for CL dynamic localization in bacterial cells are discussed. In the mitochondrial membrane CL is involved in organization of multi-subunit oxidative phosphorylation complexes and in their association into higher order supercomplexes. Evidence suggesting a possible role for CL in concert with ATP synthase oligomers in establishing mitochondrial cristae morphology is presented. Hypotheses on CL-dependent dynamic re-organization of the respiratory chain in response to changes in metabolic states and CL dynamic re-localization in mitochondria during the apoptotic response are briefly addressed.

Indexed as

AnimalsCardiolipinsCell MembraneEukaryotic CellsHumansProkaryotic CellsCardiolipins

Identifiers

PMID19371718
PMCPMC2757463
OpenAlexW2108325229

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.