ArticleImmunity2009
Protein kinase D is an essential regulator of C. elegans innate immunity.
Article in Immunity, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
50 citing papers in PubMed, 83 citations in OpenAlex.
- Article
- Endosomal catabolism of phosphatidylinositol 4,5-bisphosphate is fundamental in building resilience against pathogens.Protein & cell · 2025Article
- Berberine hydrochloride enhances innate immunity to protect against pathogen infection via p38 MAPK pathway.Frontiers in immunology · 2025Article
- Immunity-linked genes are stimulated by a membrane stress pathway linked to Golgi function and the ARF-1 GTPase.Science advances · 2023Article
- The homeodomain transcription factor CEH-37 regulates PMK-1/p38 MAPK pathway to protect against intestinal infection via the phosphatase VHP-1.Cellular and molecular life sciences : CMLS · 2023Article
- The p38 MAPK/PMK-1 Pathway Is Required for Resistance toPathogens (Basel, Switzerland) · 2022Article
- Article
- Immunomodulatory and Antiaging Mechanisms of Resveratrol, Rapamycin, and Metformin: Focus on mTOR and AMPK Signaling Networks.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Sanguinarine promotes healthspan and innate immunity through a conserved mechanism of ROS-mediated PMK-1/SKN-1 activation.iScience · 2022Article
- The redundancy and diversity between two novel PKC isotypes that regulate learning inProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Assessment of the effects of organic vs. inorganic arsenic and mercury inCurrent research in toxicology · 2022Article
- Take a Walk to the Wild Side ofMicrobiology and molecular biology reviews : MMBR · 2021Review
- Article
- Caenorhabditis elegans saposin-like spp-9 is involved in specific innate immune responses.Genes and immunity · 2020Article
- Protein Kinase D Is Dispensable for Development and Survival ofG3 (Bethesda, Md.) · 2019Article
- RIOK-1 Is a Suppressor of the p38 MAPK Innate Immune Pathway inFrontiers in immunology · 2018Article
- TheeLife · 2017Article
- Mitochondrial chaperone HSP-60 regulates anti-bacterial immunity via p38 MAP kinase signaling.The EMBO journal · 2017Article
- A Novel Conserved Domain Mediates Dimerization of Protein Kinase D (PKD) Isoforms: DIMERIZATION IS ESSENTIAL FOR PKD-DEPENDENT REGULATION OF SECRETION AND INNATE IMMUNITY.The Journal of biological chemistry · 2016Article
- An Evolutionarily Conserved PLC-PKD-TFEB Pathway for Host Defense.Cell reports · 2016Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Protein kinase D (PKD) mediates signal transduction downstream from phospholipase C and diacylglycerol (DAG). PKDs are activated by hormones and stress in cell lines, but little is known about PKD functions and regulation in vivo. Here, we show that DKF-2, a C. elegans PKD, regulates innate immunity. Animals lacking DKF-2 were hypersensitive to killing by bacteria that are pathogens of C. elegans and humans. DKF-2 induced 85 mRNAs, which encode antimicrobial peptides and proteins that sustain intestinal epithelium. Induction of immune effector mRNAs by DKF-2 proceeded via PMK-1 (p38 Map-kinase)-dependent and -independent pathways. TPA-1, a PKCdelta homolog, regulated activation and functions of DKF-2 in vivo. Therefore, DKF-2 provides a molecular link that couples DAG signaling to regulation of immunity. This intersection between DAG-TPA-1-DKF-2 and PMK-1 pathways enables integrated immune responses to multiple stimuli. Thus, a PKD mobilizes activation of host immune defenses against pathogens by previously unappreciated signaling pathways and mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.