ArticleNitric oxide : biology and chemistry2009
Plasma nitrite response and arterial reactivity differentiate vascular health and performance.
Article in Nitric oxide : biology and chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed.
- Moderate dose of dietary nitrate improves skeletal muscle microvascular function in patients with peripheral artery disease.Microvascular research · 2023Trial
- On the implication of dietary nitrate supplementation for the hemodynamic and fatigue response to cycling exercise.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Trial
- Body mass-normalized moderate dose of dietary nitrate intake improves endothelial function and walking capacity in patients with peripheral artery disease.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Trial
- Inorganic nitrate supplementation enhances functional capacity and lower-limb microvascular reactivity in patients with peripheral artery disease.Nitric oxide : biology and chemistry · 2018Trial
- Beet the Best?Circulation research · 2018Trial
- Acute ingestion of dietary nitrate increases muscle blood flow via local vasodilation during handgrip exercise in young adults.Physiological reports · 2018Trial
- Plasma nitrite is an indicator of acute changes in ambient air pollutant concentrations.Inhalation toxicology · 2014Trial
- Isolation of functional human endothelial cells from small volumes of umbilical cord blood.Annals of biomedical engineering · 2013Trial
- Single-dose pharmacokinetics of different oral sodium nitrite formulations in diabetes patients.Diabetes technology & therapeutics · 2012Trial
- Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.Journal of applied physiology (Bethesda, Md. : 1985) · 2011Trial
- Plasma nitrite flux predicts exercise performance in peripheral arterial disease after 3months of exercise training.Free radical biology & medicine · 2010Trial
- Individualised Exercise Training Enhances Antioxidant Buffering Capacity in Idiopathic Pulmonary Fibrosis.Antioxidants (Basel, Switzerland) · 2023Article
- Impaired microcirculatory function, mitochondrial respiration, and oxygen utilization in skeletal muscle of claudicating patients with peripheral artery disease.American journal of physiology. Heart and circulatory physiology · 2022Article
- Targeting HIF2α-ARNT hetero-dimerisation as a novel therapeutic strategy for pulmonary arterial hypertension.The European respiratory journal · 2021Article
- Regenerated Microvascular Networks in Ischemic Skeletal Muscle.Frontiers in physiology · 2021Article
- Obstruction of Small Arterioles in Patients with Critical Limb Ischemia due to Partial Endothelial-to-Mesenchymal Transition.iScience · 2020Article
- Systemic translation of locally infiltrated epidermal growth factor in diabetic lower extremity wounds.International wound journal · 2019Article
- Effects of a novel hydrogen sulfide prodrug in a porcine model of acute limb ischemia.Journal of vascular surgery · 2019Article
- The Microbiome and Endothelial Function.Circulation research · 2018Article
- Exercise intolerance in Type 2 diabetes: is there a cardiovascular contribution?Journal of applied physiology (Bethesda, Md. : 1985) · 2018Review
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6 authors.
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Abstract
NO is crucial for endothelial function and vascular health. Plasma nitrite (NO(2)(-)) is the main oxidation product of NO and has been shown to reflect changes in eNOS activity. We hypothesized that plasma NO(2)(-) response to physical exercise stress along with physiological endothelial function would be reduced with increasing severity of vascular disease. Subject groups were: (a) risk factors but no vascular disease (RF); (b) Type 2 diabetes with no vascular disease (DM); (c) diagnosed peripheral arterial disease (PAD); and (d) DM+PAD. Venous blood was drawn at rest and 10min following maximal exercise. Plasma samples were analyzed by reductive chemiluminescence. Brachial diameters were imaged prior to, during and following 5min of forearm occlusion (BAFMD). There were no differences in resting plasma NO(2)(-) or BA diameters between groups. The PAD groups had lower age adjusted BAFMD responses (p0.05). Within group analysis revealed an increase in NO(2)(-) in the RF group (+39.3%), no change in the DM (-15.51%), and a decrease in the PAD (-44.20%) and PAD+DM (-39.95%). This was maintained after adjusting for age and VO(2peak) (p0.05). DeltaNO(2)(-) and BAFMD were the strongest independent predictors of VO(2peak) in multivariate linear regression. These findings suggest DeltaNO(2)(-) discriminates severity of cardiovascular disease risk, is related to endothelial function and predicts exercise capacity.
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