ArticleJournal of biology2009
Conservation of core gene expression in vertebrate tissues.
Article in Journal of biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 113 papers, 1 of them a synthesis that pooled it.
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Who cites it
113 citing papers in PubMed, 1 synthesis or guideline pooled it, 196 citations in OpenAlex.
- Meta-analysis of RNA-seq expression data across species, tissues and studies.Genome biology · 2015Pooled it
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- The molecular evolution of vertebrate organs.Nature ecology & evolution · 2026Review
- Gene function predicts divergence across molecular levels.bioRxiv : the preprint server for biology · 2026Article
- Ortholog transfer stress test: Regulatory edge conservation across species, tissues, and evolutionary distance.PloS one · 2026Article
- Exploring the roles of conserved context-dependent cis-regulatory elements (cdCREs) in multicellularity, human health and disease.The FEBS journal · 2025Review
- Saliva Protein Genes in Humans were Shaped During Primate Evolution.Genome biology and evolution · 2025Article
- Evolution of the essential geneProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Splicing is dynamically regulated during limb development.Scientific reports · 2024Article
- Gene expression supports a single origin of horns and antlers in hoofed mammals.Communications biology · 2024Article
- Emergence of saliva protein genes in the secretory calcium-binding phosphoprotein (SCPP) locus and accelerated evolution in primates.bioRxiv : the preprint server for biology · 2024Article
- RNA-Seq based selection signature analysis for identifying genomic footprints associated with the fat-tail phenotype in sheep.Frontiers in veterinary science · 2024Article
- Current advances in primate genomics: novel approaches for understanding evolution and disease.Nature reviews. Genetics · 2023Review
- Convergent genomics of longevity in rockfishes highlights the genetics of human life span variation.Science advances · 2023Article
- Stochastic Modeling of Gene Expression Evolution Uncovers Tissue- and Sex-Specific Properties of Expression Evolution in theJournal of computational biology : a journal of computational molecular cell biology · 2023Article
- Meta-analysis of RNA-Seq datasets highlights novel genes/pathways involved in fat deposition in fat-tail of sheep.Frontiers in veterinary science · 2023Article
- Extensive Adaptive Variation in Gene Expression within and between Closely Related Horseshoe Bats (Chiroptera,Animals : an open access journal from MDPI · 2022Article
- Endogenous retroviruses co-opted as divergently transcribed regulatory elements shape the regulatory landscape of embryonic stem cells.Nucleic acids research · 2022Article
- regCNN: identifyingComputational and structural biotechnology journal · 2022Article
53 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
backgroundVertebrates share the same general body plan and organs, possess related sets of genes, and rely on similar physiological mechanisms, yet show great diversity in morphology, habitat and behavior. Alteration of gene regulation is thought to be a major mechanism in phenotypic variation and evolution, but relatively little is known about the broad patterns of conservation in gene expression in non-mammalian vertebrates.
resultsWe measured expression of all known and predicted genes across twenty tissues in chicken, frog and pufferfish. By combining the results with human and mouse data and considering only ten common tissues, we have found evidence of conserved expression for more than a third of unique orthologous genes. We find that, on average, transcription factor gene expression is neither more nor less conserved than that of other genes. Strikingly, conservation of expression correlates poorly with the amount of conserved nonexonic sequence, even using a sequence alignment technique that accounts for non-collinearity in conserved elements. Many genes show conserved human/fish expression despite having almost no nonexonic conserved primary sequence.
conclusionsThere are clearly strong evolutionary constraints on tissue-specific gene expression. A major challenge will be to understand the precise mechanisms by which many gene expression patterns remain similar despite extensive cis-regulatory restructuring.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.