ArticleBMC cancer2009
Contamination and sample mix-up can best explain some patterns of mtDNA instabilities in buccal cells and oral squamous cell carcinoma.
Article in BMC cancer, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The saga of the many studies wrongly associating mitochondrial DNA with breast cancer.BMC cancer · 2014Pooled it
- Molecular oncology focus - is carcinogenesis a 'mitochondriopathy'?Journal of biomedical science · 2010Pooled it
- Profiling of Mitochondrial DNA Heteroplasmy in a Prospective Oral Squamous Cell Carcinoma Study.Cancers · 2020Article
- A New Paradigm for Tissue Diagnostics: Tools and Techniques to Standardize Tissue Collection, Transport, and Fixation.Current pathobiology reports · 2018Review
- Patterns of cross-contamination in a multispecies population genomic project: detection, quantification, impact, and solutions.BMC biology · 2017Article
- The complete mitogenome of a 500-year-old Inca child mummy.Scientific reports · 2015Article
- Mitochondrial DNA mutations in single human blood cells.Mutation research · 2015Review
- SASI-Seq: sample assurance Spike-Ins, and highly differentiating 384 barcoding for Illumina sequencing.BMC genomics · 2014Article
- Review
- The maintenance of mitochondrial genetic stability is crucial during the oncogenic process.Communicative & integrative biology · 2012Article
- Mitochondrial subversion in cancer.Cancer prevention research (Philadelphia, Pa.) · 2011Review
- The role of the mitochondrial genome in ageing and carcinogenesis.Journal of aging research · 2011Article
- A statistical framework for the interpretation of mtDNA mixtures: forensic and medical applications.PloS one · 2011Article
- Article
- Potential pitfalls in MitoChip detected tumor-specific somatic mutations: a call for caution when interpreting patient data.BMC cancer · 2010Article
- Mitochondrial DNA mutation in normal margins and tumors of recurrent head and neck squamous cell carcinoma patients.Cancer prevention research (Philadelphia, Pa.) · 2010Article
- eCOMPAGT integrates mtDNA: import, validation and export of mitochondrial DNA profiles for population genetics, tumour dynamics and genotype-phenotype association studies.BMC bioinformatics · 2010Article
- mtDNA data mining in GenBank needs surveying.American journal of human genetics · 2009Article
- Article
- Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The study of somatic DNA instabilities constitutes a debatable topic because different causes can lead to seeming DNA alteration patterns between different cells or tissues from the same individual. Carcinogenesis or the action of a particular toxic could generate such patterns, and this is in fact the leitmotif of a number of studies on mitochondrial DNA (mtDNA) instability. Patterns of seeming instabilities could also arise from technical errors at any stage of the analysis (DNA extraction, amplification, mutation screening/sequencing, and documentation). Specifically, inadvertent DNA contamination or sample mixing would yield mosaic variation that could be erroneously interpreted as real mutation differences (instabilities) between tissues from the same individual. From the very beginning, mtDNA studies comparing cancerous to non-cancerous tissues have suffered from such mosaic results. We demonstrate here that the phylogenetic linkage of whole arrays of mtDNA mutations provides strong evidence of artificial recombination in previous studies on buccal cells and oral squamous cell carcinoma.
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