ArticleDiagnostic pathology2009
Mortality in human sepsis is associated with downregulation of Toll-like receptor 2 and CD14 expression on blood monocytes.
Article in Diagnostic pathology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
37 citing papers in PubMed, 70 citations in OpenAlex.
- Restoration of anti-bacterial innate immune cell function lags behind nutritional recovery among children convalescing from complicated severe acute malnutrition.Nature communications · 2026Article
- Search for Potential VDR/Partner Composite Elements in Regulatory DNA of Genes Associated with Respiratory Infections and Atopic Diseases.International journal of molecular sciences · 2025Article
- Disease activity and immune disbalance are key drivers of infections in patients with idiopathic inflammatory myopathies: results from the MYOTReCSZ cohort.Immunologic research · 2025Article
- Interpreting biologically informed neural networks for enhanced proteomic biomarker discovery and pathway analysis.Nature communications · 2023Article
- MSM Supplementation Is Associated with Reduced Inflammation and Improved Innate Immune Response following In Vitro LPS-Stimulation in Humans after a Bout of Downhill Running.Muscles (Basel, Switzerland) · 2023Article
- Evidence for Monocyte Reprogramming in a Long-Term Postsepsis Study.Critical care explorations · 2022Article
- Resolvin D2 promotes host defense in a 2 - hit model of sepsis with secondary lung infection.Prostaglandins & other lipid mediators · 2022Article
- Article
- Machine learning identification of specific changes in myeloid cell phenotype during bloodstream infections.Scientific reports · 2021Article
- Monocyte subset distribution and surface expression of HLA-DR and CD14 in patients after cardiopulmonary resuscitation.Scientific reports · 2021Article
- Diagnostic, Prognostic, Predictive, and Monitoring Role of Neutrophil CD11b and Monocyte CD14 in Neonatal Sepsis.Disease markers · 2021Article
- Toll-like receptor 2 downregulation and cytokine dysregulation predict mortality in patients with Staphylococcus aureus bacteremia.BMC infectious diseases · 2020Article
- Effect of zinc supplementation on relative expression of immune response genes in neonates with sepsis: A preliminary study.The Indian journal of medical research · 2020Article
- Infection-induced innate antimicrobial response disorders: from signaling pathways and their modulation to selected biomarkers.Central-European journal of immunology · 2020Review
- Association between disease-related malnutrition and innate immunity gene expression in critically ill patients at intensive care unit admission.Central-European journal of immunology · 2020Article
- Early measurement of IL-10 predicts the outcomes of patients with acute respiratory distress syndrome receiving extracorporeal membrane oxygenation.Scientific reports · 2017Article
- Inflammasome and toll-like receptor signaling in human monocytes after successful cardiopulmonary resuscitation.Critical care (London, England) · 2016Article
- Dysregulation of signaling pathways associated with innate antibacterial immunity in patients with pancreatic cancer.Central-European journal of immunology · 2016Review
- Innate immunity gene expression changes in critically ill patients with sepsis and disease-related malnutrition.Central-European journal of immunology · 2015Article
- Evaluation of Toll-like, chemokine, and integrin receptors on monocytes and neutrophils from peripheral blood of septic patients and their correlation with clinical outcomes.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2014Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pattern recognition receptors are a key component of the first line host defense against infection, recognizing specific microbial products. We hypothesize that monocyte hyporesponsiveness in human sepsis is associated with a downregulation of the pattern recognition receptors Toll-like receptor (TLR)-2 and TLR4.Protein expression of CD14, TLR2 and TLR4 on blood monocytes was examined using flow cytometry from 29 patients with sepsis and 14 healthy controls. In addition LPS stimulated TNF-alpha and IL-10 production was studied in a 24 hour whole blood assay.We found an increased expression of CD14, TLR2 and TLR4 in patients with sepsis compared to controls (p < 0.01). In patients with sepsis, death was associated with significant lower CD14 and TLR2 expression at admission (CD14: 25.7 +- 19.1 vs 39.1 +- 17.3 mean fluorescence intensity [MFI], p = 0.02; TLR2: 21.8 +- 9.4 vs. 30.9 +- 9.6, p = 0.01). At 72 hours the TLR2 expression on monocytes was associated with the IL-10 inducibility after LPS stimulation (r = 0.52, p = 0.02) and the CD14 expression with the IL-6, IL-10 and TNF inducibility.We conclude that septic patients are characterized by an increased expression of CD14, TLR2 and TLR4 on monocytes compared to controls. Death is associated with downregulation of TLR2 and CD14 expression on monocytes correlating with reduced cytokine inducibility. We suggest that CD14 and TLR2 are a key factor in monocyte hyporesponsibility during severe sepsis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.