ReviewBritish journal of pharmacology2009
Opportunities for the replacement of animals in the study of nausea and vomiting.
Review in British journal of pharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Systematic review of the training process of minimally invasive surgery in neonates and infants.Pediatric surgery international · 2025Pooled it
- The role of the parasympathetic nervous system in visually induced motion sickness: systematic review and meta-analysis.Experimental brain research · 2014Pooled it
- Predicting the emetic liability of novel chemical entities: a comparative study.British journal of pharmacology · 2012Pooled it
- Cisplatin-induced emesis: systematic review and meta-analysis of the ferret model and the effects of 5-HT₃ receptor antagonists.Cancer chemotherapy and pharmacology · 2011Pooled it
- Placebo effects on nausea and motion sickness are resistant to experimentally-induced stress.Scientific reports · 2023Trial
- Review
- D-pinitol modulates the anti-emetic effects of aprepitant, domperidone, and ondansetron in chicks.Pharmaceutical science advances · 2025Article
- Molecular and neural basis of vomiting behavior inScience advances · 2025Article
- A deep learning-based system for automatic detection of emesis with high accuracy in Suncus murinus.Communications biology · 2025Article
- Evaluating the Presence of Disgust in Animals.Animals : an open access journal from MDPI · 2024Review
- Article
- Assessment of Quercetin Antiemetic Properties: In Vivo and In Silico Investigations on Receptor Binding Affinity and Synergistic Effects.Plants (Basel, Switzerland) · 2023Article
- An assay of drug-induced emesis in the squirrel monkey (Saimiri sciureus).Journal of medical primatology · 2019Article
- Safety of xylo-oligosaccharides (XOS) as a novel food pursuant to Regulation (EU) 2015/2283.EFSA journal. European Food Safety Authority · 2018Article
- A History of Drug Discovery for Treatment of Nausea and Vomiting and the Implications for Future Research.Frontiers in pharmacology · 2018Review
- Article
- Anti-nausea effects and pharmacokinetics of ondansetron, maropitant and metoclopramide in a low-dose cisplatin model of nausea and vomiting in the dog: a blinded crossover study.BMC veterinary research · 2017Article
- What is nausea? A historical analysis of changing views.Autonomic neuroscience : basic & clinical · 2017Review
- Involvement of Cannabinoid Signaling in Vincristine-Induced Gastrointestinal Dysmotility in the Rat.Frontiers in pharmacology · 2017Article
- Cannabinoids As Potential Treatment for Chemotherapy-Induced Nausea and Vomiting.Frontiers in pharmacology · 2016Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nausea and vomiting are among the most common symptoms encountered in medicine as either symptoms of disease or side effects of treatments. Developing novel anti-emetics and identifying emetic liability in novel chemical entities rely on models that can recreate the complexity of these multi-system reflexes. Animal models (especially the ferret and dog) are the current gold standard; however, the selection of appropriate models is still a matter of debate, especially when studying the subjective human sensation of nausea. Furthermore, these studies are associated with animal suffering. Here, following a recent workshop held to review the utility of animal models in nausea and vomiting research, we discuss the limitations of some of the current models in the context of basic research, anti-emetic development and emetic liability detection. We provide suggestions for how these limitations may be overcome using non-animal alternatives, including greater use of human volunteers, in silico and in vitro techniques and lower organisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.