ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie1991
Blood-retina barrier permeability and its relation to the progression of diabetic retinopathy in type 1 diabetics. An 8-year follow-up study.
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 28 citations in OpenAlex.
- The diabetic ocular environment facilitates the development of endogenous bacterial endophthalmitis.Investigative ophthalmology & visual science · 2012Article
- Inhibition of advanced glycation and absence of galectin-3 prevent blood-retinal barrier dysfunction during short-term diabetes.Experimental diabetes research · 2007Article
- Neuroprotective and blood-retinal barrier-preserving effects of cannabidiol in experimental diabetes.The American journal of pathology · 2006Article
- Experimental diabetes causes breakdown of the blood-retina barrier by a mechanism involving tyrosine nitration and increases in expression of vascular endothelial growth factor and urokinase plasminogen activator receptor.The American journal of pathology · 2003Article
- Diabetic macular oedema: a comparison of vitreous fluorometry, angiography, and retinopathy.The British journal of ophthalmology · 2002Article
- Permeability of the blood-retinal barrier in healthy humans. European Concerted Action on Ocular Fluorometry.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 1997Article
- Analysis of the blood-retinal barrier: its relation to clinical and metabolic factors and progression to retinopathy in juvenile diabetics. A 4-year follow-up study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 1996Article
- Blood-retinal barrier permeability and its relation to progression of retinopathy in patients with type 2 diabetes. A four-year follow-up study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 1993Article
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3 authors at 1 institution in 1 country.
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Abstract
Blood-retina barrier (BRB) permeability and its relation to the progression of diabetic retinopathy was studied over an 8-year period in 50 insulin-dependent diabetic patients. Initially, the patients underwent an ophthalmological examination, including measurement of best corrected visual acuity, fundus photography and vitreous fluorometry for determination of BRB permeability. After 8 years the patients were reexamined and their retinal status and clinical course were evaluated. We found a positive correlation between a high initial permeability value and an unfavorable clinical course using the parameter photocoagulation. A decrease in follow-up visual acuity was also associated with high initial permeability; however, this correlation was not statistically significant. A significant difference in mean blood pressure was found between values measured in laser-treated patients vs a group that did not undergo such therapy. Thus, in patients showing the same initial retinal morphology, high permeability seems to indicate an unfavorable disease course. The extent to which BRB permeability can be a valuable supplement to fluorescein angiography and three-mirror examination in the clinical decision process needs to be further evaluated.
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