Trial reportPsychopharmacology2009
Acute tryptophan depletion evokes negative mood in healthy females who have previously experienced concurrent negative mood and tryptophan depletion.
Trial report in Psychopharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- Acute tryptophan depletion increases translational indices of anxiety but not fear: serotonergic modulation of the bed nucleus of the stria terminalis?Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012Trial
- 5-HT modulation of pain perception in humans.Psychopharmacology · 2017Article
- Optimization of L-Tryptophan Biosynthesis From L-Serine of Processed Iranian Beet and Cane Molasses and Indole by Induced Escherichia coli ATCC 11303 Cells.Jundishapur journal of microbiology · 2014Article
- The effect of acute tryptophan depletion on mood and impulsivity in polydrug ecstasy users.Psychopharmacology · 2014Article
- Serotonin and aversive Pavlovian control of instrumental behavior in humans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Depressed mood enhances anxiety to unpredictable threat.Psychological medicine · 2012Article
- The ethics of elective psychopharmacology.The international journal of neuropsychopharmacology · 2012Review
- Tryptophan depletion disinhibits punishment but not reward prediction: implications for resilience.Psychopharmacology · 2012Article
- The effect of induced anxiety on cognition: threat of shock enhances aversive processing in healthy individuals.Cognitive, affective & behavioral neuroscience · 2011Article
- Psychological stress-induced, IDO1-dependent tryptophan catabolism: implications on immunosuppression in mice and humans.PloS one · 2010Article
- Specificity of the acute tryptophan and tyrosine plus phenylalanine depletion and loading tests I. Review of biochemical aspects and poor specificity of current amino Acid formulations.International journal of tryptophan research : IJTR · 2010Article
- Specificity of the Acute Tryptophan and Tyrosine Plus Phenylalanine Depletion and Loading Tests Part II: Normalisation of the Tryptophan and the Tyrosine Plus Phenylalanine to Competing Amino Acid Ratios in a New Control Formulation.International journal of tryptophan research : IJTR · 2010Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
introductionThe majority of individuals who suffer an episode of depression go on to experience recurrences. We have proposed, based upon the observation that reducing serotonin via acute tryptophan depletion (ATD) is more likely to induce negative mood in recovered depressed individuals than never depressed individuals, that this may be because associations form between negative mood and reduced serotonin during an episode of depression (Robinson and Sahakian, Psychol Med 38:315-318, 2008b). Such associations would mean that subsequent reductions in serotonin are more likely to provoke depressed mood and hence trigger an episode of depression.
methodsIn this study, we tested this hypothesis by manipulating the mood state of healthy females undergoing ATD (or balanced placebo) on two separate testing sessions. On the first session, subjects received either negative or neutral mood induction, while on the second session all subjects received neutral mood induction.
resultsOur findings demonstrate significant ATD-induced negative mood exclusively on the second visit of subjects who received both ATD and negative mood induction procedure on their first visit. DISCUSSION: These findings may be explained by the formation of an association between the negative mood and reduced serotonin states during the first visit. As such, these findings provide preliminary support for the associative hypothesis of recurrence in depression.
conclusionSuch associations might therefore explain the discrepancy between the effects of ATD in recovered- and never-depressed individuals and may, in turn, explain why an episode of depression increases the risk of subsequent episodes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.