ArticleTAG. Theoretical and applied genetics. Theoretische und angewandte Genetik2009
Mutations of the multi-drug resistance-associated protein ABC transporter gene 5 result in reduction of phytic acid in rice seeds.
Article in TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 95 citations in OpenAlex.
- Genome-Wide Analyses of the SoybeanGenes · 2025Article
- Identification of a novel mutation in theFrontiers in plant science · 2024Article
- An Overview of Targeted Genome Editing Strategies for Reducing the Biosynthesis of Phytic Acid: an Anti-nutrient in Crop Plants.Molecular biotechnology · 2024Review
- Genetic Localization and Homologous Genes Mining for Barley Grain Size.International journal of molecular sciences · 2023Review
- The suppression of TdMRP3 genes reduces the phytic acid and increases the nutrient accumulation in durum wheat grain.Frontiers in plant science · 2023Article
- 2021 update on ATP-binding cassette (ABC) transporters: how they meet the needs of plants.Plant physiology · 2021Review
- Integrating a genome-wide association study with transcriptomic data to predict candidate genes and favourable haplotypes influencing Brassica napus seed phytate.DNA research : an international journal for rapid publication of reports on genes and genomes · 2021Article
- Network Inference of Transcriptional Regulation in Germinating Low Phytic Acid Soybean Seeds.Frontiers in plant science · 2021Article
- Globoids and Phytase: The Mineral Storage and Release System in Seeds.International journal of molecular sciences · 2020Review
- Genome-Wide Identification of Barley ABC Genes and Their Expression in Response to Abiotic Stress Treatment.Plants (Basel, Switzerland) · 2020Article
- Comparative Root Transcriptomics Provide Insights into Drought Adaptation Strategies in Chickpea (International journal of molecular sciences · 2020Article
- Phytic Acid and Transporters: What Can We Learn fromPlants (Basel, Switzerland) · 2020Review
- Genetic interactions regulating seed phytate and oligosaccharides in soybean (Glycine max L.).PloS one · 2020Article
- MRP Transporters andFrontiers in plant science · 2020Review
- Knockout ofFrontiers in plant science · 2020Article
- Mutation ofPlants (Basel, Switzerland) · 2019Article
- Novel allelic variant of Lpa1 gene associated with a significant reduction in seed phytic acid content in rice (Oryza sativa L.).PloS one · 2019Article
- Development and Molecular Characterization of Low Phytate Basmati Rice Through Induced Mutagenesis, Hybridization, Backcross, and Marker Assisted Breeding.Frontiers in plant science · 2019Article
- Molecular modeling and3 Biotech · 2018Article
- Inference of Transcription Regulatory Network in Low Phytic Acid Soybean Seeds.Frontiers in plant science · 2017Article
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Authors and funding
7 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phytic acid (PA, myo-inositol 1,2,3,4,5,6-hexakisphosphate) is important to the nutritional quality of cereal and legume seeds. PA and its salts with micronutrient cations, such as iron and zinc, cannot be digested by humans and non-ruminant animals, and hence may affect food/feed nutritional value and cause P pollution of groundwater from animal waste. We previously developed a set of low phytic acid (LPA) rice mutant lines with the aim of increasing the nutritional quality of rice. Two of these lines, Os-lpa-XS110-2 (homozygous non-lethal) Os-lpa-XS110-3 (homozygous lethal), contain two mutant alleles of a LPA gene (hereafter XS-lpa2-1 and XS-lpa2-2, respectively). In this study, we mapped the XS-lpa2-1 gene to a region on chromosome 3 between microsatellite markers RM14360 and RM1332, where the rice orthologue (OsMRP5) of the maize lpa1 gene is located. Sequence analysis of the OsMRP5 gene revealed a single base pair change (C/G-T/A transition) in the sixth exon of XS-lpa2-1 and a 5-bp deletion in the first exon of XS-lpa2-2. OsMRP5 is expressed in both vegetative tissues and developing seeds, and the two mutations do not change the level of RNA transcription. A T-DNA insertion line, 4A-02500, in which OsMRP5 was disrupted, also showed the same high inorganic phosphorus phenotype as Os-lpa-XS110-3 and appeared to be homozygous lethal. PA is significantly reduced in Os-lpa-XS110-2 (~20%) and in 4A-02500 (~90%) seeds compared with their wild type lines, and no PA was detected in Os-lpa-XS110-3 using HPLC analysis. This evidence indicates that the OsMRP5 gene plays an important role in PA metabolism in rice seeds.
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