Evidence map›Paper›PMID 19370312›Full record

ReviewCellular and molecular life sciences : CMLS2009

Cytoskeleton-membrane interactions in membrane raft structure.

Gurunadh R Chichili, William Rodgers

Abstract readReview
In one paragraph

Review in Cellular and molecular life sciences : CMLS, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 115 papers.

0numbers the graph read from it
0cells of the map it votes in
115citing papers in PubMed
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

115 citing papers in PubMed, 225 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Polyphenols fromMembranes · 2025
    Article
  5. Protein interactions, calcium, phosphorylation, and cholesterol modulate CFTR cluster formation on membranes.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Article
  7. Polar Glycerolipids and Membrane Lipid Rafts.International journal of molecular sciences · 2024
    Review
  8. Dynamized ultra-low dilution ofCell adhesion & migration · 2023
    Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. PIPCell calcium · 2021
    Article
  17. Article
  18. Review
  19. Critical Phenomena in Plasma Membrane Organization and Function.Annual review of physical chemistry · 2021
    Review
  20. Review

55 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Gurunadh R ChichiliCardiovascular Biology Research Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA.
William Rodgers
Oklahoma Medical Research Foundation · US

Funding

GEM Domains and T cell signalingR01GM070001 · NIGMS · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI RODGERS, WILLIAM A · 2003 to 2007
$1.3M
NIGMS NIH HHS R01 GM 070001NIGMS NIH HHS R01 GM070001
6 · The paper itself

Abstract

Cell membranes are structurally heterogeneous, composed of discrete domains with unique physical and biological properties. Membrane domains can form through a number of mechanisms involving lipid-lipid and protein-lipid interactions. One type of membrane domain is the cholesterol-dependent membrane raft. How rafts form remains a current topic in membrane biology. We review here evidence of structuring of rafts by the cortical actin cytoskeleton. This includes evidence that the actin cytoskeleton associates with rafts, and that many of the structural and functional properties of rafts require an intact actin cytoskeleton. We discuss the mechanisms of the actin-dependent raft organization, and the properties of the actin cytoskeleton in regulating raft-associated signaling events. We end with a discussion of membrane rafts and the actin cytoskeleton in T cell activation, which function synergistically to initiate the adaptive immune response.

Indexed as

ActinsAnimalsCell MembraneCytoskeletonHumansLymphocyte ActivationMembrane MicrodomainsModels, BiologicalPhosphatidylinositol 4,5-DiphosphateSignal TransductionT-LymphocytesActinsPhosphatidylinositol 4,5-Diphosphate

Identifiers

PMID19370312
PMCPMC2709161
OpenAlexW2070487296

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.