ArticleThe EMBO journal2009
Sua5p a single-stranded telomeric DNA-binding protein facilitates telomere replication.
Article in The EMBO journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 36 citations in OpenAlex.
- The functionality of telomerase depends on CPF-CF induced 3'end processing of its RNA component TLC1 and a novel Nrd1-Nab3 surveillance mechanism.Nucleic acids research · 2025Article
- A paralog of Pcc1 is the fifth core subunit of the KEOPS tRNA-modifying complex in Archaea.Nature communications · 2023Article
- Biallelic variants in YRDC cause a developmental disorder with progeroid features.Human genetics · 2021Article
- The structural and functional workings of KEOPS.Nucleic acids research · 2021Review
- Structure of a reaction intermediate mimic in t6A biosynthesis bound in the active site of the TsaBD heterodimer from Escherichia coli.Nucleic acids research · 2021Article
- Swc4 positively regulates telomere length independently of its roles in NuA4 and SWR1 complexes.Nucleic acids research · 2020Article
- Review
- KEOPS complex promotes homologous recombination via DNA resection.Nucleic acids research · 2019Article
- Tethering telomerase to telomeres increases genome instability and promotes chronological aging in yeast.Aging · 2016Article
- Structural and functional characterization of KEOPS dimerization by Pcc1 and its role in t6A biosynthesis.Nucleic acids research · 2016Article
- Global translational impacts of the loss of the tRNA modification tMicrobial cell (Graz, Austria) · 2016Article
- Inhibition of telomere recombination by inactivation of KEOPS subunit Cgi121 promotes cell longevity.PLoS genetics · 2015Article
- The emerging role of complex modifications of tRNAMicrobial cell (Graz, Austria) · 2015Article
- Telomere recombination preferentially occurs at short telomeres in telomerase-null type II survivors.PloS one · 2014Article
- Reconstitution and characterization of eukaryotic N6-threonylcarbamoylation of tRNA using a minimal enzyme system.Nucleic acids research · 2013Article
- Telomerase-null survivor screening identifies novel telomere recombination regulators.PLoS genetics · 2013Article
- Everything you ever wanted to know about Saccharomyces cerevisiae telomeres: beginning to end.Genetics · 2012Review
- The tail-module of yeast Mediator complex is required for telomere heterochromatin maintenance.Nucleic acids research · 2012Article
- Gcn4 misregulation reveals a direct role for the evolutionary conserved EKC/KEOPS in the t6A modification of tRNAs.Nucleic acids research · 2011Article
- The highly conserved KEOPS/EKC complex is essential for a universal tRNA modification, t6A.The EMBO journal · 2011Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In budding yeast Saccharomyces cerevisiae, telomere length maintenance involves a complicated network as more than 280 telomere maintenance genes have been identified in the nonessential gene deletion mutant set. As a supplement, we identified additional 29 telomere maintenance genes, which were previously taken as essential genes. In this study, we report a novel function of Sua5p in telomere replication. Epistasis analysis and telomere sequencing show that sua5Delta cells display progressively shortened telomeres at early passages, and Sua5 functions downstream telomerase recruitment. Further, biochemical, structural and genetic studies show that Sua5p specifically binds single-stranded telomeric (ssTG) DNA in vitro through a distinct DNA-binding region on its surface, and the DNA-binding ability is essential for its telomere function. Thus, Sua5p represents a novel ssTG DNA-binding protein and positively regulates the telomere length in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.