ArticleAnti-cancer drugs2009
The marine alkaloid naamidine A promotes caspase-dependent apoptosis in tumor cells.
Article in Anti-cancer drugs, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 45 citations in OpenAlex.
- TargetingFrontiers in bioinformatics · 2025Article
- A cytotoxic survey on 2-amino-1H-imidazol based synthetic marine sponge alkaloid analogues.Drug development research · 2022Article
- Cancer and apoptosis: The apoptotic activity of plant and marine natural products and their potential as targeted cancer therapeutics.Frontiers in pharmacology · 2022Review
- Bioactive Compounds from Marine Heterobranchs.Marine drugs · 2020Review
- Retracted Article: The synthesis and biological activity of marine alkaloid derivatives and analogues.RSC advances · 2020Article
- A Cancer-Selective Zinc Ionophore Inspired by the Natural Product Naamidine A.ACS chemical biology · 2019Article
- The Potential of Indonesian Heterobranchs Found around Bunaken Island for the Production of Bioactive Compounds.Marine drugs · 2017Review
- Marine Sponge Natural Products with Anticancer Potential: An Updated Review.Marine drugs · 2017Review
- Total synthesis and cytotoxicity of Leucetta alkaloids.Bioorganic & medicinal chemistry · 2017Article
- Marine Natural Products from New Caledonia--A Review.Marine drugs · 2016Review
- Synthesis of Naamidine A and Selective Access to N(2)-Acyl-2-aminoimidazole Analogues.The Journal of organic chemistry · 2015Article
- Article
- Synthesis and biological evaluation of novel 3-alkylpyridine marine alkaloid analogs with promising anticancer activity.Marine drugs · 2014Article
- Total syntheses and cytotoxicity of kealiiquinone, 2-deoxy-2-aminokealiiquinone and analogs.Bioorganic & medicinal chemistry letters · 2013Article
- Synthesis of the reported structures for kealiinines B and C.Organic letters · 2012Article
- A journey under the sea: the quest for marine anti-cancer alkaloids.Molecules (Basel, Switzerland) · 2011Review
- Recently confirmed apoptosis-inducing lead compounds isolated from marine sponge of potential relevance in cancer treatment.Marine drugs · 2011Review
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 3 countries.
Funding
Abstract
Apoptosis is important for normal development and removal of damaged cells. Evasion of apoptosis by cancer cells is one of the key characteristics of many tumor types. Thus, discovering agents that promote apoptosis in tumor cells could have great therapeutic value. Marine natural products have demonstrated great potential as anticancer agents, and the proapoptotic activity of some of these products is emerging as a potentially useful property for cancer treatments. Using a tumor xenograft assay in rodents, we previously found that the marine alkaloid naamidine A is a potent antitumor agent. In this study, we further characterize the mechanism of action of naamidine A. In cultured tumor cells, we find that naamidine A induces cell death, which is accompanied with annexin V staining, disruption of the mitochondrial membrane potential, and cleavage and activation of caspases 3, 8, and 9, all of which are hallmarks of apoptosis. Furthermore, naamidine A-induced cell death is caspase dependent. We also find that under conditions where naamidine A inhibits tumor xenograft growth, it induces activation of caspase 3, suggesting that apoptosis is part of its antitumorigenic activity in vivo. Apoptosis is not dependent on extracellular signal-regulated kinase 1/2, previously characterized molecular targets of naamidine A, nor does it require functional p53. Our studies support the continued study of naamidine A and its target(s) for the potential development of better clinical treatments for cancer.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.