SynthesisThe New England journal of medicine2009
Genomewide association studies of stroke.
Synthesis in The New England journal of medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 231 papers, 24 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
231 citing papers in PubMed, 24 syntheses or guidelines pooled it, 462 citations in OpenAlex.
- The Role of Genetics in Stroke Risk and Outcome: A Review of Current Evidence.Brain and behavior · 2025Pooled it
- Genetic association of ANRIL with susceptibility to Ischemic stroke: A comprehensive meta-analysis.PloS one · 2022Pooled it
- Pooled it
- Strong impact of natural-selection-free heterogeneity in genetics of age-related phenotypes.Aging · 2018Pooled it
- Pleiotropic Associations of Allelic Variants in a 2q22 Region with Risks of Major Human Diseases and Mortality.PLoS genetics · 2016Pooled it
- Identification of additional risk loci for stroke and small vessel disease: a meta-analysis of genome-wide association studies.The Lancet. Neurology · 2016Pooled it
- Low-frequency and common genetic variation in ischemic stroke: The METASTROKE collaboration.Neurology · 2016Pooled it
- Genome-Wide Association Analysis of Young-Onset Stroke Identifies a Locus on Chromosome 10q25 Near HABP2.Stroke · 2016Pooled it
- Meta-Analysis of Genome-Wide Association Studies Identifies Genetic Risk Factors for Stroke in African Americans.Stroke · 2015Pooled it
- Birth Cohort, Age, and Sex Strongly Modulate Effects of Lipid Risk Alleles Identified in Genome-Wide Association Studies.PloS one · 2015Pooled it
- Guideline
- Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease.Nature genetics · 2014Pooled it
- Pooled it
- Pooled it
- Association between 9p21 genomic markers and ischemic stroke risk: evidence based on 21 studies.PloS one · 2014Pooled it
- Pooled it
- Rs2200733 and rs10033464 on chromosome 4q25 confer risk of cardioembolic stroke: an updated meta-analysis.Molecular biology reports · 2013Pooled it
- Pooled it
- Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies.The Lancet. Neurology · 2012Pooled it
- Polymorphism of tumor necrosis factor alpha (TNF-alpha) gene promoter, circulating TNF-alpha level, and cardiovascular risk factor for ischemic stroke.Journal of neuroinflammation · 2012Pooled it
171 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
46 authors at 17 institutions in 3 countries.
Funding
Abstract
backgroundThe genes underlying the risk of stroke in the general population remain undetermined.
methodsWe carried out an analysis of genomewide association data generated from four large cohorts composing the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium, including 19,602 white persons (mean [+/-SD] age, 63+/-8 years) in whom 1544 incident strokes (1164 ischemic strokes) developed over an average follow-up of 11 years. We tested the markers most strongly associated with stroke in a replication cohort of 2430 black persons with 215 incident strokes (191 ischemic strokes), another cohort of 574 black persons with 85 incident strokes (68 ischemic strokes), and 652 Dutch persons with ischemic stroke and 3613 unaffected persons.
resultsTwo intergenic single-nucleotide polymorphisms on chromosome 12p13 and within 11 kb of the gene NINJ2 were associated with stroke (P<5x10(-8)). NINJ2 encodes an adhesion molecule expressed in glia and shows increased expression after nerve injury. Direct genotyping showed that rs12425791 was associated with an increased risk of total (i.e., all types) and ischemic stroke, with hazard ratios of 1.30 (95% confidence interval [CI], 1.19 to 1.42) and 1.33 (95% CI, 1.21 to 1.47), respectively, yielding population attributable risks of 11% and 12% in the discovery cohorts. Corresponding hazard ratios were 1.35 (95% CI, 1.01 to 1.79; P=0.04) and 1.42 (95% CI, 1.06 to 1.91; P=0.02) in the large cohort of black persons and 1.17 (95% CI, 1.01 to 1.37; P=0.03) and 1.19 (95% CI, 1.01 to 1.41; P=0.04) in the Dutch sample; the results of an underpowered analysis of the smaller black cohort were nonsignificant.
conclusionsA genetic locus on chromosome 12p13 is associated with an increased risk of stroke.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.