ArticleBiology of reproduction2009
Murine endometrial and decidual NK1.1+ natural killer cells display a B220+CD11c+ cell surface phenotype.
Article in Biology of reproduction, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- Differential modulation of gestational immunity by fatty acids: tissue-specific immune remodeling and clinical implications.Clinical science (London, England : 1979) · 2026Article
- Innate Lymphoid Cells in Reproductive Health and Disease.European journal of immunology · 2025Review
- Innate Immune Mechanisms in Normal and Adverse Pregnancy.Advances in experimental medicine and biology · 2025Review
- Natural Killer Cells, as the Rising Point in Tissues, Are Forgotten in the Kidney.Biomolecules · 2023Review
- Addressing Natural Killer Cell Dysfunction and Plasticity in Cell-Based Cancer Therapeutics.Cancers · 2023Review
- Erbu Zhuyu decoction improves endometrial angiogenesis via uterine natural killer cells and the PI3K/Akt/eNOS pathway a mouse model of embryo implantation dysfunction.American journal of reproductive immunology (New York, N.Y. : 1989) · 2023Article
- Single-Cell RNA-Sequencing Reveals Interactions between Endometrial Stromal Cells, Epithelial Cells, and Lymphocytes during Mouse Embryo Implantation.International journal of molecular sciences · 2022Article
- The enrichment of neutrophil extracellular traps impair the placentas of systemic lupus erythematosus through accumulating decidual NK cells.Scientific reports · 2021Article
- Uterine Natural Killer Cells: Functional Distinctions and Influence on Pregnancy in Humans and Mice.Frontiers in immunology · 2017Review
- The Residual Innate Lymphoid Cells in NFIL3-Deficient Mice Support Suboptimal Maternal Adaptations to Pregnancy.Frontiers in immunology · 2016Article
- Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface.Journal of visualized experiments : JoVE · 2015Article
- Article
- Uterine NK cells: active regulators at the maternal-fetal interface.The Journal of clinical investigation · 2014Review
- Tissue-resident natural killer cells and their potential diversity.Seminars in immunology · 2014Review
- In vivo generation of decidual natural killer cells from resident hematopoietic progenitors.Haematologica · 2014Article
- Ly49 receptors: innate and adaptive immune paradigms.Frontiers in immunology · 2014Review
- Article
- Article
- Murine trophoblast cells induce NK cell interferon-gamma production through KLRK1.Biology of reproduction · 2010Article
- Immune surveillance of the maternal/fetal interface: controversies and implications.Trends in endocrinology and metabolism: TEM · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Uterine natural killer (uNK) cells accumulate at the maternal-fetal interface during gestation and are thought to have an important role during pregnancy in both mice and humans. While the cell surface phenotype of human uNK cells is increasingly well defined, less is known regarding the cell surface expression profile of murine uNK cells both before and during gestation. Herein, we demonstrate that murine NK1.1(+) (KLRB1C) endometrial NK (eNK) cells, derived from virgin mice, and NK1.1(+) decidual NK (dNK) cells, obtained from pregnant mice, belong to the B220(+) (PTPRC) CD11c(+) (ITGAX) subset of NK cells. While B220 expression was low on NK1.1(+) eNK cells, it was increased on a subset of NK1.1(+) dNK cells at Embryonic Day 10.5. Endometrial NK and dNK cells also differed somewhat in their expression patterns of two activation markers, namely, CD69 and inducible costimulator (ICOS). The eNK cells acquired a B220(hi)ICOS(+) dNK cell surface phenotype when cultured in vitro in the presence of uterine cells and murine interleukin 15. Thus, the cell surface profiles generated for both NK1.1(+) eNK cells and dNK cells demonstrate that they belong to the recently described B220(+)CD11c(+) subset of NK cells, which are potent cytokine producers.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.