ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2009
Severe spontaneous bradycardia associated with respiratory disruptions in rat pups with fewer brain stem 5-HT neurons.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 50 citations in OpenAlex.
- Protocol for simultaneous non-invasive electrocardiogram and respiratory plethysmography recordings in mice.STAR protocols · 2026Article
- Reducing the risk of sudden unexpected infant death: the caffeine hypothesis.Journal of perinatology : official journal of the California Perinatal Association · 2025Review
- Inhibition of microtubule detyrosination by parthenolide facilitates functional CNS axon regeneration.eLife · 2023Article
- Selective Serotonin Reuptake Inhibitors and 5-HTNeuroscience · 2023Article
- Transneuronal delivery of hyper-interleukin-6 enables functional recovery after severe spinal cord injury in mice.Nature communications · 2021Article
- Sudden infant death syndrome: Melatonin, serotonin, and CD34 factor as possible diagnostic markers and prophylactic targets.PloS one · 2021Article
- Sex- and age-based differences in the effect of central serotonin on arterial blood pressure regulation.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- The serotonergic system and the control of breathing during development.Respiratory physiology & neurobiology · 2019Review
- Head Rules Over the Heart: Cardiac Manifestations of Cerebral Disorders.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2019Review
- Increased central cholinergic drive contributes to the apneas of serotonin-deficient rat pups during active sleep.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- Pre- and early postnatal nicotine exposure exacerbates autoresuscitation failure in serotonin-deficient rat neonates.The Journal of physiology · 2018Article
- The central role of serotonin.eLife · 2018Article
- Effects of neonatal hyperoxia on the critical period of postnatal development of neurochemical expressions in brain stem respiratory-related nuclei in the rat.Physiological reports · 2018Article
- Central serotonin and the control of arterial blood pressure and heart rate in infant rats: influence of sleep state and sex.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- Active sleep unmasks apnea and delayed arousal in infant rat pups lacking central serotonin.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Article
- Neurocardiology: Cardiovascular Changes and Specific Brain Region Infarcts.BioMed research international · 2017Review
- Eliminating medullary 5-HT neurons delays arousal and decreases the respiratory response to repeated episodes of hypoxia in neonatal rat pups.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- Influence of developmental nicotine exposure on the ventilatory and metabolic response to hyperthermia.The Journal of physiology · 2015Article
- Intermittent hypercapnia enhances CO₂ responsiveness and overcomes serotonergic dysfunction.Respiratory physiology & neurobiology · 2014Article
- The physiological determinants of sudden infant death syndrome.Respiratory physiology & neurobiology · 2013Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The medullary 5-HT system has potent effects on heart rate and breathing in adults. We asked whether this system mitigates the respiratory instability and bradycardias frequently occurring during the neonatal period. 5,7-Dihydroxytryptamine (5,7-DHT) or vehicle was administered to rat pups at postnatal day 2 (P2), and we then compared the magnitude of bradycardias occurring with disruptions to eupnea in treated and vehicle control littermates at P5-6 and P10-12. We then used a novel method that would allow accurate assessment of the ventilatory and heart rate responses to near square-wave challenges of hypoxia (10% O2), hypercapnia (5 and 8% CO2 in normoxia and hyperoxia), and asphyxia (8% CO2-10% O2), and to the induction of the Hering-Breuer inflation reflex (HBR), a potent, apnea-inducing reflex in newborns. The number of 5-HT-positive neurons was reduced approximately 80% by drug treatment. At both ages, lesioned animals had considerably larger bradycardias during brief apnea; at P5-6, average and severe events were approximately 50% and 70% greater, respectively, in lesioned animals (P = 0.002), whereas at P10-12, events were approximately 23% and 50% greater (P = 0.018). However, lesioning had no effect on the HR responses to sudden gas challenge or the HBR. At P5-6, lesioned animals had reduced breathing frequency and ventilation (Ve), but normal Ve relative to metabolic rate (Ve/Vo2). At P10-12, lesioned animals had a more unstable breathing pattern (P = 0.04) and an enhanced Ve response to moderate hypercapnia (P = 0.007). Within the first two postnatal weeks, the medullary 5-HT system plays an important role in cardiorespiratory control, mitigating spontaneous bradycardia, stabilizing the breathing pattern, and dampening the hypercapnic Ve response.
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