ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
Functionally reduced sensorimotor connections form with normal specificity despite abnormal muscle spindle development: the role of spindle-derived neurotrophin 3.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 47 citations in OpenAlex.
- Vocal learning-associated convergent evolution in mammalian proteins and regulatory elements.Science (New York, N.Y.) · 2024Article
- Serotonergic dysfunction impairs locomotor coordination in spinal muscular atrophy.Brain : a journal of neurology · 2023Article
- Structural Preservation Does Not Ensure Function at Sensory Ia-Motoneuron Synapses following Peripheral Nerve Injury and Repair.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Matrine promotes neural circuit remodeling to regulate motor function in a mouse model of chronic spinal cord injury.Neural regeneration research · 2019Article
- Subtype Diversification and Synaptic Specificity of Stem Cell-Derived Spinal Interneurons.Neuron · 2018Article
- Molecular mechanisms underlying monosynaptic sensory-motor circuit development in the spinal cord.Developmental dynamics : an official publication of the American Association of Anatomists · 2018Review
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- Reduced sensory synaptic excitation impairs motor neuron function via Kv2.1 in spinal muscular atrophy.Nature neuroscience · 2017Article
- Dicer maintains the identity and function of proprioceptive sensory neurons.Journal of neurophysiology · 2017Article
- Gamma motor neurons survive and exacerbate alpha motor neuron degeneration in ALS.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Requirement for Dicer in Maintenance of Monosynaptic Sensory-Motor Circuits in the Spinal Cord.Cell reports · 2016Article
- Sensory-Derived Glutamate Regulates Presynaptic Inhibitory Terminals in Mouse Spinal Cord.Neuron · 2016Article
- Role of primary afferents in the developmental regulation of motor axon synapse numbers on Renshaw cells.The Journal of comparative neurology · 2016Article
- Synapse Formation in Monosynaptic Sensory-Motor Connections Is Regulated by Presynaptic Rho GTPase Cdc42.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Article
- Egr3-dependent muscle spindle stretch receptor intrafusal muscle fiber differentiation and fusimotor innervation homeostasis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- The PDZ-domain protein Whirlin facilitates mechanosensory signaling in mammalian proprioceptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Article
- V1 and v2b interneurons secure the alternating flexor-extensor motor activity mice require for limbed locomotion.Neuron · 2014Article
- Early postnatal development of GABAergic presynaptic inhibition of Ia proprioceptive afferent connections in mouse spinal cord.Journal of neurophysiology · 2013Article
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4 authors at 2 institutions in 1 country.
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Abstract
The mechanisms controlling the formation of synaptic connections between muscle spindle afferents and spinal motor neurons are believed to be regulated by factors originating from muscle spindles. Here, we find that the connections form with appropriate specificity in mice with abnormal spindle development caused by the conditional elimination of the neuregulin 1 receptor ErbB2 from muscle precursors. However, despite a modest ( approximately 30%) decrease in the number of afferent terminals on motor neuron somata, the amplitude of afferent-evoked synaptic potentials recorded in motor neurons was reduced by approximately 80%, suggesting that many of the connections that form are functionally silent. The selective elimination of neurotrophin 3 (NT3) from muscle spindles had no effect on the amplitude of afferent-evoked ventral root potentials until the second postnatal week, revealing a late role for spindle-derived NT3 in the functional maintenance of the connections. These findings indicate that spindle-derived factors regulate the strength of the connections but not their initial formation or their specificity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.