ArticleMolecular biology of the cell2009
LKB1 catalytic activity contributes to estrogen receptor alpha signaling.
Article in Molecular biology of the cell, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 40 citations in OpenAlex.
- Tumor suppressors LKB1 and SMARCA4 functionally interact to regulate gene expression across diverse biological processes in lung cancer.Frontiers in cell and developmental biology · 2026Article
- Integrative Machine Learning Model for Overall Survival Prediction in Breast Cancer Using Clinical and Transcriptomic Data.Biology · 2025Article
- Gene function revealed at the moment of stochastic gene silencingCommunications biology · 2025Article
- Liver Kinase B1-A Potential Therapeutic Target in Hormone-Sensitive Breast Cancer in Older Women.Cancers · 2019Article
- Genomic-Epidemiologic Evidence That Estrogens Promote Breast Cancer Development.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2018Article
- Expression of3 Biotech · 2017Article
- Article
- Large-Scale Profiling of Kinase Dependencies in Cancer Cell Lines.Cell reports · 2016Article
- Clinical Relevance of Liver Kinase B1(LKB1) Protein and Gene Expression in Breast Cancer.Scientific reports · 2016Article
- Oestrogen receptors interact with the α-catalytic subunit of AMP-activated protein kinase.Bioscience reports · 2015Article
- Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression.Carcinogenesis · 2015Review
- Pre-clinical study of drug combinations that reduce breast cancer burden due to aberrant mTOR and metabolism promoted by LKB1 loss.Oncotarget · 2014Article
- Loss of LKB1 disrupts breast epithelial cell polarity and promotes breast cancer metastasis and invasion.Journal of experimental & clinical cancer research : CR · 2014Article
- Expression and transcriptional profiling of the LKB1 tumor suppressor in cervical cancer cells.Gynecologic oncology · 2014Article
- LKB1 suppresses proliferation and invasion of prostate cancer through hedgehog signaling pathway.International journal of clinical and experimental pathology · 2014Article
- Omega-3 polyunsaturated fatty acid promotes the inhibition of glycolytic enzymes and mTOR signaling by regulating the tumor suppressor LKB1.Cancer biology & therapy · 2013Article
- Loss of LKB1 expression reduces the latency of ErbB2-mediated mammary gland tumorigenesis, promoting changes in metabolic pathways.PloS one · 2013Article
- The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK.Nature chemical biology · 2012Article
- Honokiol activates AMP-activated protein kinase in breast cancer cells via an LKB1-dependent pathway and inhibits breast carcinogenesis.Breast cancer research : BCR · 2012Article
- The LKB1 complex-AMPK pathway: the tree that hides the forest.Familial cancer · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The tumor suppressor serine-threonine kinase LKB1 is mutated in Peutz-Jeghers syndrome (PJS) and in epithelial cancers, including hormone-sensitive organs such as breast, ovaries, testes, and prostate. Clinical studies in breast cancer patients show low LKB1 expression is related to poor prognosis, whereas in PJS, the risk of breast cancer is similar to the risk from germline mutations in breast cancer (BRCA) 1/BRCA2. In this study, we investigate the role of LKB1 in estrogen receptor alpha (ERalpha) signaling. We demonstrate for the first time that LKB1 binds to ERalpha in the cell nucleus in which it is recruited to the promoter of ERalpha-responsive genes. Furthermore, LKB1 catalytic activity enhances ERalpha transactivation compared with LKB1 catalytically deficient mutants. The significance of our discovery is that we demonstrate for the first time a novel functional link between LKB1 and ERalpha. Our discovery places LKB1 in a coactivator role for ERalpha signaling, broadening the scientific scope of this tumor suppressor kinase and laying the groundwork for the use of LKB1 as a target for the development of new therapies against breast cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.