ArticleJournal of virology2009
Dissecting the functional domains of a nonenveloped virus membrane penetration peptide.
Article in Journal of virology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Structure-based simulations of the full Flock House virus capsid reveal pathways and energetics of infection-critical peptide externalization.Biophysical journal · 2026Article
- Atomistic dynamics of a viral infection process: Release of membrane lytic peptides from a non-enveloped virus.Science advances · 2021Article
- Structural and dynamic asymmetry in icosahedrally symmetric virus capsids.Current opinion in virology · 2020Review
- Molecular dynamics study of membrane permeabilization by wild-type and mutant lytic peptides from the non-enveloped Flock House virus.Biochimica et biophysica acta. Biomembranes · 2020Article
- Structural Dynamics of Nonenveloped Virus Disassembly Intermediates.Journal of virology · 2019Article
- Membranotropic peptides mediating viral entry.Peptide science (Hoboken, N.J.) · 2018Review
- Folding a viral peptide in different membrane environments: pathway and sampling analyses.Journal of biological physics · 2018Article
- Curating viscoelastic properties of icosahedral viruses, virus-based nanomaterials, and protein cages.Journal of biological physics · 2018Article
- Influence of membrane composition on the binding and folding of a membrane lytic peptide from the non-enveloped flock house virus.Biochimica et biophysica acta. Biomembranes · 2017Article
- Confessions of an icosahedral virus crystallographer.Microscopy (Oxford, England) · 2013Review
- Dissecting quasi-equivalence in nonenveloped viruses: membrane disruption is promoted by lytic peptides released from subunit pentamers, not hexamers.Journal of virology · 2012Article
- Strategies for antiviral screening targeting early steps of virus infection.Virologica Sinica · 2010Review
- An N-terminal domain of adenovirus protein VI fragments membranes by inducing positive membrane curvature.Virology · 2010Article
- NMR structure of a viral peptide inserted in artificial membranes: a view on the early steps of the birnavirus entry process.The Journal of biological chemistry · 2010Article
- Evolution in action: N and C termini of subunits in related T = 4 viruses exchange roles as molecular switches.Structure (London, England : 1993) · 2010Article
- Structure and function of a genetically engineered mimic of a nonenveloped virus entry intermediate.Journal of virology · 2010Article
- Low endocytic pH and capsid protein autocleavage are critical components of Flock House virus cell entry.Journal of virology · 2009Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Recent studies have established that several nonenveloped viruses utilize virus-encoded lytic peptides for host membrane disruption. We investigated this mechanism with the "gamma" peptide of the insect virus Flock House virus (FHV). We demonstrate that the C terminus of gamma is essential for membrane disruption in vitro and the rescue of immature virus infectivity in vivo, and the amphipathic N terminus of gamma alone is not sufficient. We also show that deletion of the C-terminal domain disrupts icosahedral ordering of the amphipathic helices of gamma in the virus. Our results have broad implications for understanding membrane lysis during nonenveloped virus entry.
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Registered trials
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