Trial reportBiological psychiatry2009
Serotonin modulation of cerebral glucose metabolism in depressed older adults.
Trial report in Biological psychiatry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 58 citations in OpenAlex.
- Acute effects of selective serotonin reuptake inhibitors on cerebral glucose metabolism and blood flow.Translational psychiatry · 2026Trial
- Lack of association between pretreatment glutamate/GABA and major depressive disorder treatment response.Translational psychiatry · 2025Trial
- Serotonin transporter occupancy and the functional neuroanatomic effects of citalopram in geriatric depression.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2011Trial
- Functional connectivity patterns of the subgenual anterior cingulate cortex in first-episode refractory major depressive disorder.Brain imaging and behavior · 2021Article
- Molecular imaging of the serotonin transporter availability and occupancy by antidepressant treatment in late-life depression.Neuropharmacology · 2021Article
- Abnormal Default Mode Network Homogeneity in Treatment-Naive Patients With First-Episode Depression.Frontiers in psychiatry · 2018Article
- Molecular imaging of serotonin degeneration in mild cognitive impairment.Neurobiology of disease · 2017Article
- Depressive symptoms accelerate cognitive decline in amyloid-positive MCI patients.European journal of nuclear medicine and molecular imaging · 2015Observational
- Disproportionate Reduction of Serotonin Transporter May Predict the Response and Adherence to Antidepressants in Patients with Major Depressive Disorder: A Positron Emission Tomography Study with 4-[18F]-ADAM.The international journal of neuropsychopharmacology · 2015Article
- The relationship between fasting serum glucose and cerebral glucose metabolism in late-life depression and normal aging.Psychiatry research · 2014Article
- Positron emission tomography molecular imaging in late-life depression.Journal of geriatric psychiatry and neurology · 2014Review
- Abnormal default-mode network homogeneity in first-episode, drug-naive major depressive disorder.PloS one · 2014Article
- Neuropsychiatric symptoms in Alzheimer's disease: past progress and anticipation of the future.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2013Review
- Metabolic imaging of bilateral anterior capsulotomy in refractory obsessive compulsive disorder: an FDG PET study.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2013Article
- Longitudinal studies of cerebral glucose metabolism in late-life depression and normal aging.International journal of geriatric psychiatry · 2013Article
- Serotonin modulation of cerebral glucose metabolism: sex and age effects.Synapse (New York, N.Y.) · 2012Article
- Stability in brain glucose metabolism following brown adipose tissue inactivation in chinese adults.AJNR. American journal of neuroradiology · 2012Article
- Neuron density and serotonin receptor binding in prefrontal cortex in suicide.The international journal of neuropsychopharmacology · 2012Article
- Distinct functional networks associated with improvement of affective symptoms and cognitive function during citalopram treatment in geriatric depression.Human brain mapping · 2011Article
- Neuropsychiatric symptoms in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundMonoamine dysfunction, particularly of the serotonin system, has been the dominant hypothesis guiding research and treatment development in affective disorders. The majority of research has been performed in midlife depressed adults. The importance of understanding the neurobiology of depression in older adults is underscored by increased rates of mortality and completed suicide and an increased risk of Alzheimer's dementia. To evaluate the dynamic response of the serotonin system, the acute effects of citalopram infusion on cerebral glucose metabolism was measured in depressed older adults and control subjects. The hypothesis was tested that smaller decreases in metabolism would be observed in cortical and limbic regions in depressed older adults relative to control subjects.
methodsSixteen depressed older adults and 13 control subjects underwent two resting positron emission tomography (PET) studies with the radiotracer [18F]-2-deoxy-2-fluoro-D-glucose after placebo and citalopram infusions.
resultsIn control subjects compared with depressed older adults, greater citalopram-induced decreases in cerebral metabolism were observed in the right anterior cingulate, middle temporal (bilaterally), left precuneus, and left parahippocampal gyri. Greater decreases in the depressed older adults than control subjects were observed in left superior and left middle frontal gyri and increases in left inferior parietal lobule, left cuneus, left thalamus, and right putamen.
conclusionsIn depressed older adults relative to control subjects, the cerebral metabolic response to citalopram is blunted in cortico-cortical and cortico-limbic pathways and increased in the left hemisphere (greater decrease interiorly and increases posteriorly). These findings suggest both blunted and compensatory cerebral metabolic responses to citalopram in depressed older adults.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.