ArticleStructure (London, England : 1993)2009
The crystal structure of cobra venom factor, a cofactor for C3- and C5-convertase CVFBb.
Article in Structure (London, England : 1993), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 35 citations in OpenAlex.
- Ancient Secretory Pathways Contributed to the Evolutionary Origin of an Ecologically Impactful Bioluminescence System.Molecular biology and evolution · 2024Article
- CG001, a C3b-targeted complement inhibitor, blocks 3 complement pathways: development and preclinical evaluation.Blood advances · 2024Article
- The Role of the Complement System in Synaptic Pruning after Stroke.Aging and disease · 2024Review
- Technique for xenogeneic cross-circulation to support human donor lungs ex vivo.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2023Article
- Targeting complement components C3 and C5 for the retina: Key concepts and lingering questions.Progress in retinal and eye research · 2021Review
- Human Neutrophils Respond to Complement Activation and Inhibition in Microfluidic Devices.Frontiers in immunology · 2021Article
- Complement depletion with cobra venom factor alleviates acute hepatic injury induced by ischemia‑reperfusion.Molecular medicine reports · 2018Article
- Inhibition of the alternative complement pathway preserves photoreceptors after retinal injury.Science translational medicine · 2015Article
- The structure and function of thioester-containing proteins in arthropods.Biophysical reviews · 2014Article
- Structure of Streptococcus agalactiae tip pilin GBS104: a model for GBS pili assembly and host interactions.Acta crystallographica. Section D, Biological crystallography · 2013Article
- Putting the structure into complement.Immunobiology · 2012Review
- Substrate recognition by complement convertases revealed in the C5-cobra venom factor complex.The EMBO journal · 2011Article
- Insights into complement convertase formation based on the structure of the factor B-cobra venom factor complex.The EMBO journal · 2009Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Cobra venom factor (CVF) is a functional analog of human complement component C3b, the active fragment of C3. Similar to C3b, in human and mammalian serum, CVF binds factor B, which is then cleaved by factor D, giving rise to the CVFBb complex that targets the same scissile bond in C3 as the authentic complement convertases C4bC2a and C3bBb. Unlike the latter, CVFBb is a stable complex and an efficient C5 convertase. We solved the crystal structure of CVF, isolated from Naja naja kouthia venom, at 2.6 A resolution. The CVF crystal structure, an intermediate between C3b and C3c, lacks the TED domain and has the CUB domain in an identical position to that seen in C3b. The similarly positioned CUB and slightly displaced C345c domains of CVF could play a vital role in the formation of C3 convertases by providing important primary binding sites for factor B.
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