ArticleStructure (London, England : 1993)2009
Synergy of NMR, computation, and X-ray crystallography for structural biology.
Article in Structure (London, England : 1993), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 66 citations in OpenAlex.
- Computational Strategies for Discovering Inhibitors Targeting Therapeutic Enzymes.Methods in molecular biology (Clifton, N.J.) · 2026Article
- MnM-W-MMGBSA: A Computational Strategy to Improve Relative Binding Free Energies of Protein-Protein Interaction Systems.The journal of physical chemistry. B · 2025Article
- Organic-solvent mediated self-assembly of protoporphyrin IX with human serum albumin.International journal of biological macromolecules · 2025Article
- Exploring the dynamics of allostery through multi-dimensional crystallography.Biophysical reviews · 2024Review
- Navigating the Frontiers of Machine Learning in Neurodegenerative Disease Therapeutics.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Optimal selection of suitable templates in protein interface prediction.Bioinformatics (Oxford, England) · 2023Article
- Article
- Structures of filamentous viruses infecting hyperthermophilic archaea explain DNA stabilization in extreme environments.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Solvent-Dependent Structures of Natural Products Based on the Combined Use of DFT Calculations andMolecules (Basel, Switzerland) · 2019Article
- Structure and mechanism of cancer-associated N-acetylglucosaminyltransferase-V.Nature communications · 2018Article
- Structural studies ofProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Viruses of archaea: Structural, functional, environmental and evolutionary genomics.Virus research · 2018Review
- The enigmatic archaeal virosphere.Nature reviews. Microbiology · 2017Review
- Article
- Article
- Large Tailed Spindle Viruses of Archaea: a New Way of Doing Viral Business.Journal of virology · 2015Review
- Virology. A virus that infects a hyperthermophile encapsidates A-form DNA.Science (New York, N.Y.) · 2015Article
- Archaeal extrachromosomal genetic elements.Microbiology and molecular biology reviews : MMBR · 2015Review
- Genomics and biology of Rudiviruses, a model for the study of virus-host interactions in Archaea.Biochemical Society transactions · 2013Review
- A survey of protein structures from archaeal viruses.Life (Basel, Switzerland) · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
NMR spectroscopy and X-ray crystallography are currently the two most widely applied methods for the determination of macromolecular structures at high resolution. More recently, significant advances have been made in algorithms for the de novo prediction of protein structure, and, in favorable cases, the predicted models agree extremely well with experimentally determined structures. Here, we demonstrate a synergistic combination of NMR spectroscopy, de novo structure prediction, and X-ray crystallography in an effective overall strategy for rapidly determining the structure of the coat protein C-terminal domain from the Sulfolobus islandicus rod-shaped virus (SIRV). This approach takes advantage of the most accessible aspects of each structural technique and may be widely applicable for structure determination.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.