ArticleBMC public health2009
Physical and emotional health outcomes after 12 months of public-sector antiretroviral treatment in the Free State Province of South Africa: a longitudinal study using structural equation modelling.
Article in BMC public health, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Mental health and well-being of older adults living with HIV in sub-Saharan Africa: a systematic review.BMJ open · 2021Pooled it
- Trial
- Task shifting and integration of HIV care into primary care in South Africa: the development and content of the streamlining tasks and roles to expand treatment and care for HIV (STRETCH) intervention.Implementation science : IS · 2011Trial
- Quality of life and associated factors among people receiving second-line anti-retroviral therapy in Johannesburg, South Africa.BMC infectious diseases · 2022Article
- Prednisone for the prevention of tuberculosis-associated IRIS (randomized controlled trial): Impact on the health-related quality of life.Frontiers in psychology · 2022Article
- Health-related quality of life of HIV infected adults with and without Visceral Leishmaniasis in Northwest Ethiopia.Health and quality of life outcomes · 2017Article
- The mediating role of self-efficacy in the relationship between premotivational cognitions and engagement in multiple health behaviors: a theory-based cross-sectional study among township residents in South Africa.Journal of multidisciplinary healthcare · 2017Article
- Active Surveillance versus Spontaneous Reporting for First-Line Antiretroviral Medicines in Namibia: A Cost-Utility Analysis.Drug safety · 2016Article
- Health-Related Quality of Life in HIV-Infected Men Who Have Sex with Men in China: A Cross-Sectional Study.Medical science monitor : international medical journal of experimental and clinical research · 2016Article
- Finding Meaning: HIV Self-Management and Wellbeing among People Taking Antiretroviral Therapy in Uganda.PloS one · 2016Article
- Antiretroviral treatment and quality of life in Africans living with HIV: 12-month follow-up in Burkina Faso.Journal of the International AIDS Society · 2013Article
- Health, wellbeing, and disability among older people infected or affected by HIV in Uganda and South Africa.Global health action · 2013Article
- Integrating HIV care into primary care services: quantifying progress of an intervention in South Africa.PloS one · 2013Article
- An investigation of factors associated with the health and well-being of HIV-infected or HIV-affected older people in rural South Africa.BMC public health · 2012Article
- Anxiety and depression amongst patients enrolled in a public sector antiretroviral treatment programme in South Africa: a cross-sectional study.BMC public health · 2012Article
- Quality of life of people living with HIV and AIDS and antiretroviral therapy.HIV/AIDS (Auckland, N.Z.) · 2012Article
- Sexual behaviors over a 3-year period among individuals with advanced HIV/AIDS receiving antiretroviral therapy in an urban HIV clinic in Kampala, Uganda.Journal of acquired immune deficiency syndromes (1999) · 2011Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAfrican and Asian cohort studies have demonstrated the clinical efficacy of antiretroviral treatment (ART) in resource-limited settings. However, reports of the long-term changes in the physical and emotional quality of life (QoL) of patients on ART in these settings are still scarce. In this study, we assessed the physical and emotional QoL after six and 12 months of ART of a sample of 268 patients enrolled in South Africa's public-sector ART programme. The study also tested the impact of the adverse effects of medication on patients' physical and emotional QoL.
methodsA stratified random sample of 268 patients undergoing ART was interviewed at baseline (< 6 months ART) and follow-up (< 12 months ART). A model of the relationships between the duration of ART, the adverse effects of medication, and physical and emotional QoL (measured using EUROQOL-5D) was tested using structural equation modelling.
resultsThe improved physical and emotional QoL shown at baseline was sustained over the 12-month study period, because treatment duration was not significantly associated with changes in the patients' QoL. Physical QoL significantly and positively influenced the patients' emotional QoL (subjective well-being [SWB]) (beta = 0.33, P < 0.01). Longitudinal data showed that patients reported significantly fewer adverse effects at follow-up than at baseline (beta = -0.38, P < 0.001) and that these adverse effects negatively influenced physical (beta = -0.27, P < 0.01) and emotional QoL (beta = -0.15, P < 0.05).
conclusionThis study provides evidence that the South African public-sector ART programme is effective in delivering sustained improvement in patient well-being. However, the results should encourage clinicians and lay health workers to be vigilant regarding the adverse effects of treatment, because they can seriously affect physical and emotional QoL.
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