ReviewNeurogastroenterology and motility2009
Plasticity of enteric nerve functions in the inflamed and postinflamed gut.
Review in Neurogastroenterology and motility, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 90 citations in OpenAlex.
- Possible Involvement of Descending Monoaminergic Pathways in Colorectal Dysmotility Using a Rat Model of Colitis.Neurogastroenterology and motility · 2026Article
- Article
- Enteric glial S100B controls rhythmic colonic functions by regulating excitability and specificity in gut motor neurocircuits.The Journal of physiology · 2025Article
- Insights into Modeling Inflammatory Bowel Disease from Stem Cell Derived Intestinal Organoids.Stem cell reviews and reports · 2025Review
- Microbes, metabolites and (synaptic) malleability, oh my! The effect of the microbiome on synaptic plasticity.Biological reviews of the Cambridge Philosophical Society · 2022Review
- Supraspinal Mechanisms of Intestinal Hypersensitivity.Cellular and molecular neurobiology · 2022Review
- A New Target Organ ofFrontiers in cellular and infection microbiology · 2021Article
- Persistent Herpes Simplex Virus Type 1 Infection of Enteric Neurons Triggers CD8Frontiers in cellular and infection microbiology · 2021Article
- Altered brain structural connectivity in patients with longstanding gut inflammation is correlated with psychological symptoms and disease duration.NeuroImage. Clinical · 2021Article
- Gastric vagal afferent neuropathy following experimental spinal cord injury.Experimental neurology · 2020Article
- Role of Sirtuins in Modulating Neurodegeneration of the Enteric Nervous System and Central Nervous System.Frontiers in neuroscience · 2020Review
- Enteric glia regulate gut motility in health and disease.Brain research bulletin · 2018Review
- Gene-environment interactions and the enteric nervous system: Neural plasticity and Hirschsprung disease prevention.Developmental biology · 2016Review
- HIV-1 Tat exacerbates lipopolysaccharide-induced cytokine release via TLR4 signaling in the enteric nervous system.Scientific reports · 2016Article
- The Neuro-endocrinological Role of Microbial Glutamate and GABA Signaling.Frontiers in microbiology · 2016Review
- TLR4 upregulates CBS expression through NF-κB activation in a rat model of irritable bowel syndrome with chronic visceral hypersensitivity.World journal of gastroenterology · 2015Article
- Neuroprotective Potential of Mesenchymal Stem Cell-Based Therapy in Acute Stages of TNBS-Induced Colitis in Guinea-Pigs.PloS one · 2015Article
- Experimental model of tympanic colic (acute abdomen) in chinchillas (Chinchilla lanigera).Laboratory animal research · 2014Article
- Unmasking of spiral ganglion neuron firing dynamics by membrane potential and neurotrophin-3.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Cannabinoids alleviate experimentally induced intestinal inflammation by acting at central and peripheral receptors.PloS one · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Inflammation of the gut alters the properties of the intrinsic and extrinsic neurons that innervate it. While the mechanisms of neuroplasticity differ amongst the inflammatory models that have been used, amongst various regions of the gut, and between intrinsic vs extrinsic neurons, a number of consistent features have been observed. For example, intrinsic and extrinsic primary afferent neurons become hyperexcitable in response to inflammation, and interneuronal synaptic transmission is facilitated in the enteric circuitry. These changes contribute to alterations in gut function and sensation in the inflamed bowel as well as functional disorders, and these changes persist for weeks beyond the point at which detectable inflammation has subsided. Thus, gaining a more thorough understanding of the mechanisms responsible for inflammation-induced neuroplasticity, and strategies to reverse these changes are clinically relevant goals. The purpose of this review is to summarize our current knowledge regarding neurophysiological changes that occur during and following intestinal inflammation, and to identify and address gaps in our knowledge regarding the role of enteric neuroplasticity in inflammatory and functional gastrointestinal disorders.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.