ArticleACS nano2009
Protonated nanoparticle surface governing ligand tethering and cellular targeting.
Article in ACS nano, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 92 citations in OpenAlex.
- Central nervous system injury meets nanoceria: opportunities and challenges.Regenerative biomaterials · 2022Review
- Tracking interfacial single-molecule pH and binding dynamics via vibrational spectroscopy.Science advances · 2021Article
- Cerium Oxide Nanoparticles: Recent Advances in Tissue Engineering.Materials (Basel, Switzerland) · 2020Review
- Neuroprotective potential of cerium oxide nanoparticles for focal cerebral ischemic stroke.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2016Review
- Colloidal Gold-Mediated Delivery of Bleomycin for Improved Outcome in Chemotherapy.Nanomaterials (Basel, Switzerland) · 2016Article
- Cancer nanotechnology: the impact of passive and active targeting in the era of modern cancer biology.Advanced drug delivery reviews · 2014Review
- Sensitization of pancreatic cancer cells to radiation by cerium oxide nanoparticle-induced ROS production.Nanomedicine : nanotechnology, biology, and medicine · 2013Article
- Cerium oxide nanoparticles: potential applications for cancer and other diseases.American journal of translational research · 2013Article
- Catalytic nanoceria are preferentially retained in the rat retina and are not cytotoxic after intravitreal injection.PloS one · 2013Article
- Luminescent gold nanoparticles with pH-dependent membrane adsorption.Journal of the American Chemical Society · 2011Article
- Multicolored redox active upconverter cerium oxide nanoparticle for bio-imaging and therapeutics.Chemical communications (Cambridge, England) · 2010Article
- Superoxide dismutase mimics: chemistry, pharmacology, and therapeutic potential.Antioxidants & redox signaling · 2010Review
- Tuning hydrated nanoceria surfaces: experimental/theoretical investigations of ion exchange and implications in organic and inorganic interactions.Langmuir : the ACS journal of surfaces and colloids · 2010Article
- Preparation of cells for assessing ultrastructural localization of nanoparticles with transmission electron microscopy.Nature protocols · 2010Article
- Article
- Investigating the specific uptake of EGF-conjugated nanoparticles in lung cancer cells using fluorescence imaging.Cancer nanotechnologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
Nanoparticles have shown tremendous potential for effective drug delivery due to their tiny size and cell membrane penetration capabilities. Cellular targeting with nanoparticles is often achieved by surface modifications followed by ligand conjugation. However, the efficiency of the nanoparticles reaching the target cells and getting internalized depends on the stability of targeting ligands and the chemical nature of the ligand nanoparticle binding. Recent advancements in nanobiomaterials research have proven the superoxide dismutase (SOD) mimetic activity of cerium oxide nanoparticles (CNPs) in protecting cells against oxidative stress. Due to their excellent biocompatibility, CNPs can be used as a potential drug carrier that can transport and release drugs to the malignant sites. Here we combine single molecule force spectroscopy (SMFS) and density functional theory (DFT) simulations to understand the interaction between transferrin, a ligand protein overexpressed in cancer cells, and CNPs. SMFS studies demonstrate an increase in the transferrin adhesion to the nanoparticles' surface with an increase in positive zeta potential of CNPs. Binding energy values obtained from DFT calculations predict an increase in bond strength between the transferrin and CNPs upon surface protonation and charge modification. Transferrin-conjugated CNPs were tested for their binding stability and preferential cellular uptake efficiency by incubating them with human lung cancer cells (A549) and normal embryo lung cells (WI-38). The results demonstrate the importance of tuning the surface properties of nanoparticles for better ligand adsorption and cellular uptake.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.