ArticleNano letters2008
Generalized structural polymorphism in self-assembled viral particles.
Article in Nano letters, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed.
- Modeling Reveals How Direct-Acting Antivirals Redirect HBV Capsid Assembly Pathways to Noninfectious Products.bioRxiv : the preprint server for biology · 2026Article
- Computer Simulations Show That Liquid-Liquid Phase Separation Enhances Self-Assembly.ACS nano · 2025Article
- Kinetic Description of Viral Capsid Self-Assembly Using Mesoscopic Non-Equilibrium Thermodynamics.Entropy (Basel, Switzerland) · 2025Article
- Limits of economy and fidelity for programmable assembly of size-controlled triply periodic polyhedra.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Hierarchical assembly is more robust than egalitarian assembly in synthetic capsids.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Effect of ionic strength on the assembly of simian vacuolating virus capsid protein around poly(styrene sulfonate).The European physical journal. E, Soft matter · 2023Article
- Article
- Bottom-up Coarse-Graining: Principles and Perspectives.Journal of chemical theory and computation · 2022Review
- Microcompartment assembly around multicomponent fluid cargoes.The Journal of chemical physics · 2022Article
- Single-molecule biophysics experimentsiScience · 2022Article
- Minimal Design Principles for Icosahedral Virus Capsids.ACS nano · 2021Article
- Atomistic dynamics of a viral infection process: Release of membrane lytic peptides from a non-enveloped virus.Science advances · 2021Article
- Article
- In vitro assembly and evaluation of Nora virus VLPs.Acta virologica · 2021Article
- Should Virus Capsids Assemble Perfectly? Theory and Observation of Defects.Biophysical journal · 2020Article
- Geometric architecture of viruses.World journal of virology · 2020Review
- Multiscale simulation unravel the kinetic mechanisms of inflammasome assembly.Biochimica et biophysica acta. Molecular cell research · 2020Article
- The role of the encapsulated cargo in microcompartment assembly.PLoS computational biology · 2018Article
- Molecular jenga: the percolation phase transition (collapse) in virus capsids.Physical biology · 2018Article
- Geometric Defects and Icosahedral Viruses.Viruses · 2018Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The protein shells, called capsids, of nearly all spherical viruses adopt icosahedral symmetry; however, self-assembly of such empty structures often occurs with multiple misassembly steps resulting in the formation of aberrant structures. Using simple models that represent the coat proteins preassembled in the two different predetermined species that are common motifs of viral capsids (i.e., pentameric and hexameric capsomers), we perform molecular dynamics simulations of the spontaneous self-assembly of viral capsids of different sizes containing T = 1,3,4,7,9,12,13,16, and 19 proteins in their icosahedral repeating unit. We observe, in addition to icosahedral capsids, a variety of nonicosahedral yet highly ordered and enclosed capsules. Such structural polymorphism is demonstrated to be an inherent property of the coat proteins, independent of the capsid complexity and the elementary kinetic mechanisms. Moreover, there exist two distinctive classes of polymorphic structures: aberrant capsules that are larger than their respective icosahedral capsids, in T = 1-7 systems; and capsules that are smaller than their respective icosahedral capsids when T = 7-19. Different kinetic mechanisms responsible for self-assembly of those classes of aberrant structures are deciphered, providing insights into the control of the self-assembly of icosahedral capsids.
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