Evidence map›Paper›PMID 19367565›Full record

ArticlePharmacoepidemiology and drug safety2009

Colorectal cancer risk in relation to use of acid suppressive medications.

Jessica Chubak, Denise M Boudreau, Stephen J Rulyak, Margaret T Mandelson

Open access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmacoepidemiology and drug safety, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 4 pooled it
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 4 syntheses or guidelines pooled it, 40 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Jessica ChubakGroup Health Center for Health Studies, Seattle, WA 98101-1448, USA. chubak.j@ghc.org
Denise M Boudreau
Stephen J Rulyak
Margaret T Mandelson
Group Health Cooperative · USUniversity of Washington · US

Funding

Medication and Colorectal Cancer RiskR03CA110851 · NCI · GROUP HEALTH COOPERATIVE · PI BOUDREAU, DENISE M · 2004 to 2005
$160k
NCI NIH HHS CA11085NCI NIH HHS R03 CA110851
6 · The paper itself

Abstract

purposeAcid suppressants are commonly prescribed medications. Laboratory studies suggest a mechanism by which they could increase colorectal cancer (CRC) risk. A few epidemiologic studies have investigated acid suppressant use and CRC risk; none has documented an overall association. We sought to investigate whether acid suppressants are associated with CRC risk.

methodsWe conducted a case-control study among members of an integrated healthcare delivery system in Washington State. Cases (N = 641) were diagnosed with CRC between 2000 and 2003; controls (N = 641) were randomly selected from enrollees and matched to cases on age, sex, and length of enrollment. We used conditional logistic regression to estimate the odds ratios (ORs) and 95% confidence intervals (CI) for CRC associated with the use of any acid suppressive medication, proton pump inhibitors (PPIs) only, histamine receptor antagonists (H2 blockers) only, or both PPIs and H2 blockers in relation to the use of neither PPIs nor H2 blockers.

resultsUse of PPIs exclusively was modestly associated with an increased risk of CRC, however this finding was consistent with chance and based on a small number of patients exposed (OR = 1.7; 95%CI = 0.8, 4.0). H2 blocker use alone was not related to CRC risk (OR = 0.8; 95%CI = 0.6, 1.1).

conclusionsPPI use may be modestly associated with CRC risk; further research should be conducted in populations with long-term PPI use.

Indexed as

AgedAnti-Ulcer AgentsColorectal NeoplasmsFemaleHistamine H2 AntagonistsHumansMaleMiddle AgedProton Pump InhibitorsRegistriesRisk FactorsAnti-Ulcer AgentsHistamine H2 AntagonistsProton Pump Inhibitors

Identifiers

PMID19367565
PMCPMC3690626
OpenAlexW2092532233

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.