ArticleApplied microbiology and biotechnology2009
The evolution of cyclodextrin glucanotransferase product specificity.
Article in Applied microbiology and biotechnology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- An Archaeal Cyclodextrin Glycosyltransferase fromInternational journal of molecular sciences · 2026Article
- Cyclodextrin-Containing Drug Delivery Systems and Their Applications in Neurodegenerative Disorders.International journal of molecular sciences · 2024Review
- Engineering of Cyclodextrin Glycosyltransferase through a Size/Polarity Guided Triple-Code Strategy with Enhanced α-Glycosyl Hesperidin Synthesis Ability.Applied and environmental microbiology · 2022Article
- Gamma cyclodextrin glycosyltransferase from3 Biotech · 2022Article
- Engineering CGTase to improve synthesis of alkyl glycosides.Glycobiology · 2021Article
- Effect of LeuApplied and environmental microbiology · 2021Article
- Review
- MOFs as Potential Matrices in Cyclodextrin Glycosyltransferase Immobilization.Molecules (Basel, Switzerland) · 2021Review
- Engineering of Cyclodextrin Glycosyltransferase Reveals pH-Regulated Mechanism of Enhanced Long-Chain Glycosylated Sophoricoside Specificity.Applied and environmental microbiology · 2020Article
- US132 Cyclodextrin Glucanotransferase Engineering by Random Mutagenesis for an Anti-Staling Purpose.Molecular biotechnology · 2016Article
- Immobilization of Glycoside Hydrolase Families GH1, GH13, and GH70: State of the Art and Perspectives.Molecules (Basel, Switzerland) · 2016Review
- Enhancing the α-Cyclodextrin Specificity of Cyclodextrin Glycosyltransferase from Paenibacillus macerans by Mutagenesis Masking Subsite -7.Applied and environmental microbiology · 2016Article
- Genetic and rat toxicity studies of cyclodextrin glucanotransferase.Toxicology reports · 2016Article
- Molecular dynamic analysis of mutant Y195I α-cyclodextrin glycosyltransferase with switched product specificity from α-cyclodextrin to γ-cyclodextrin.Journal of molecular modeling · 2015Article
- Stepwise error-prone PCR and DNA shuffling changed the pH activity range and product specificity of the cyclodextrin glucanotransferase from an alkaliphilic Bacillus sp.FEBS open bio · 2015Article
- Cucurbitane glycosides derived from mogroside IIE: structure-taste relationships, antioxidant activity, and acute toxicity.Molecules (Basel, Switzerland) · 2014Article
- 4,6-α-Glucanotransferase activity occurs more widespread in Lactobacillus strains and constitutes a separate GH70 subfamily.Applied microbiology and biotechnology · 2013Article
- Rational mutagenesis of cyclodextrin glucanotransferase at the calcium binding regions for enhancement of thermostability.International journal of molecular sciences · 2012Article
- Identification of the sequence motif of glycoside hydrolase 13 family members.Bioinformation · 2011Article
- Thermus thermophilus glycoside hydrolase family 57 branching enzyme: crystal structure, mechanism of action, and products formed.The Journal of biological chemistry · 2011Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cyclodextrin glucanotransferases (CGTases) have attracted major interest from industry due to their unique capacity of forming large quantities of cyclic alpha-(1,4)-linked oligosaccharides (cyclodextrins) from starch. CGTases produce a mixture of cyclodextrins from starch consisting of 6 (alpha), 7 (beta) and 8 (gamma) glucose units. In an effort to identify the structural factors contributing to the evolutionary diversification of product specificity amongst this group of enzymes, we selected nine CGTases from both mesophilic, thermophilic and hyperthermophilic organisms for comparative product analysis. These enzymes displayed considerable variation regarding thermostability, initial rates, percentage of substrate conversion and ratio of alpha-, beta- and gamma-cyclodextrins formed from starch. Sequence comparison of these CGTases revealed that specific incorporation and/or substitution of amino acids at the substrate binding sites, during the evolutionary progression of these enzymes, resulted in diversification of cyclodextrin product specificity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.