ArticlePloS one2009
Inhibitory activity of myelin-associated glycoprotein on sensory neurons is largely independent of NgR1 and NgR2 and resides within Ig-Like domains 4 and 5.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 37 citations in OpenAlex.
- Probing the role of synaptic adhesion molecule RTN4RL2 in setting up cochlear connectivity.eLife · 2025Article
- Axonal growth inhibitors and their receptors in spinal cord injury: from biology to clinical translation.Neural regeneration research · 2023Review
- The NOGO receptor NgR2, a novel αVβ3 integrin effector, induces neuroendocrine differentiation in prostate cancer.Scientific reports · 2022Article
- Review
- Structural basis of myelin-associated glycoprotein adhesion and signalling.Nature communications · 2016Article
- Sialic Acid Is Required for Neuronal Inhibition by Soluble MAG but not for Membrane Bound MAG.Frontiers in molecular neuroscience · 2016Article
- Sialic Acids on Varicella-Zoster Virus Glycoprotein B Are Required for Cell-Cell Fusion.The Journal of biological chemistry · 2015Article
- Complement protein C1q modulates neurite outgrowth in vitro and spinal cord axon regeneration in vivo.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Schwann Cell Expressed Nogo-B Modulates Axonal Branching of Adult Sensory Neurons Through the Nogo-B Receptor NgBR.Frontiers in cellular neuroscience · 2015Article
- Glycogen synthase kinase 3 beta (GSK3β) at the tip of neuronal development and regeneration.Molecular neurobiology · 2014Review
- Nogo receptor homolog NgR2 expressed in sensory DRG neurons controls epidermal innervation by interaction with Versican.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Axon growth inhibition by RhoA/ROCK in the central nervous system.Frontiers in neuroscience · 2014Review
- Loss of Nogo receptor homolog NgR2 alters spine morphology of CA1 neurons and emotionality in adult mice.Frontiers in behavioral neuroscience · 2014Article
- LDL receptor-related protein-1 is a sialic-acid-independent receptor for myelin-associated glycoprotein that functions in neurite outgrowth inhibition by MAG and CNS myelin.Journal of cell science · 2013Article
- Myelin-associated proteins block the migration of olfactory ensheathing cells: an in vitro study using single-cell tracking and traction force microscopy.Cellular and molecular life sciences : CMLS · 2012Article
- Nogo receptor is involved in the adhesion of dendritic cells to myelin.Journal of neuroinflammation · 2011Article
- High affinity sialoside ligands of myelin associated glycoprotein.Bioorganic & medicinal chemistry letters · 2011Article
- Article
- Combined genetic attenuation of myelin and semaphorin-mediated growth inhibition is insufficient to promote serotonergic axon regeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Guidance molecules in axon regeneration.Cold Spring Harbor perspectives in biology · 2010Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Myelin-associated glycoprotein (MAG) is a sialic acid binding Ig-like lectin (Siglec) which has been characterized as potent myelin-derived inhibitor of neurite outgrowth. Two members of the Nogo-receptor (NgR) family, NgR1 and NgR2, have been identified as neuronal binding proteins of MAG. In addition, gangliosides have been proposed to bind to and confer the inhibitory activity of MAG on neurons. In this study, we investigated the individual contribution of NgRs and gangliosides to MAG-mediated inhibition of sensory neurons derived from dorsal root ganglia (DRG) of ngr1, ngr2 or ngr1/ngr2 deletion mutants. We found no disinhibition of neurite growth in the absence of either NgR1 or NgR2. Sensory neurons deficient for both NgR proteins displayed only a moderate reduction of MAG-mediated inhibition of neurite growth. If treated with Vibrio cholerae neuraminidase (VCN), inhibition by MAG is further attenuated but still not annulled. Thus, disrupting all known protein and ganglioside receptors for MAG in sensory neurons does not fully abolish its inhibitory activity pointing to the existence of as yet unidentified receptors for MAG. Moreover, by employing a variety of protein mutants, we identified the Ig-like domains 4 or 5 of MAG as necessary and sufficient for growth arrest, whereas abolishing MAG's ability to bind to sialic acid did not interfere with its inhibitory activity. These findings provide new insights into the inhibitory function of MAG and suggest similarities but also major differences in MAG inhibition between sensory and central nervous system (CNS) neurons.
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