ArticleEuropean journal of human genetics : EJHG2009
Genetic markers and population history: Finland revisited.
Article in European journal of human genetics : EJHG, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 88 citations in OpenAlex.
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- Y chromosome sequencing data suggest dual paths of haplogroup N1a1 into Finland.European journal of human genetics : EJHG · 2025Article
- Blood donor biobank as a resource in personalised biomedical genetic research.European journal of human genetics : EJHG · 2024Article
- Adult-Onset Neuroepidemiology in Finland: Lessons to Learn and Work to Do.Journal of clinical medicine · 2023Review
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- Regional and gender-specific analyses give new perspectives for secular trend in hip fracture incidence.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021Observational
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- A study of genomic diversity in populations of Maharashtra, India, inferred from 20 autosomal STR markers.BMC research notes · 2021Article
- Article
- The Landscape of Micro-Inversions Provide Clues for Population Genetic Analysis of Humans.Interdisciplinary sciences, computational life sciences · 2020Article
- Increasing accuracy of HLA imputation by a population-specific reference panel in a FinnGen biobank cohort.NAR genomics and bioinformatics · 2020Article
- Disparities in glioblastoma survival by case volume: a nationwide observational study.Journal of neuro-oncology · 2020Observational
- Human mitochondrial DNA lineages in Iron-Age Fennoscandia suggest incipient admixture and eastern introduction of farming-related maternal ancestry.Scientific reports · 2019Article
- Roadmap for a precision-medicine initiative in the Nordic region.Nature genetics · 2019Article
- Comparison of Herpes Simplex Virus 1 Strains Circulating in Finland Demonstrates the Uncoupling of Whole-Genome Relatedness and Phenotypic Outcomes of Viral Infection.Journal of virology · 2019Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Finnish population in Northern Europe has been a target of extensive genetic studies during the last decades. The population is considered as a homogeneous isolate, well suited for gene mapping studies because of its reduced diversity and homogeneity. However, several studies have shown substantial differences between the eastern and western parts of the country, especially in the male-mediated Y chromosome. This divergence is evident in non-neutral genetic variation also and it is usually explained to stem from founder effects occurring in the settlement of eastern Finland as late as in the 16th century. Here, we have reassessed this population historical scenario using Y-chromosomal, mitochondrial and autosomal markers and geographical sampling covering entire Finland. The obtained results suggest substantial Scandinavian gene flow into south-western, but not into the eastern, Finland. Male-biased Scandinavian gene flow into the south-western parts of the country would plausibly explain the large inter-regional differences observed in the Y-chromosome, and the relative homogeneity in the mitochondrial and autosomal data. On the basis of these results, we suggest that the expression of 'Finnish Disease Heritage' illnesses, more common in the eastern/north-eastern Finland, stems from long-term drift, rather than from relatively recent founder effects.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.