ReviewBritish journal of cancer2009
Molecular classification of solid tumours: towards pathway-driven therapeutics.
Review in British journal of cancer, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 69 citations in OpenAlex.
- Article
- Molecular Characterization of Testicular Germ Cell Tumors Using Tissue Microdissection.Methods in molecular biology (Clifton, N.J.) · 2021Review
- Molecular Signature for Lymphatic Invasion Associated with Survival of Epithelial Ovarian Cancer.Cancer research and treatment · 2018Article
- Identification of a five-lncRNA signature for the diagnosis and prognosis of gastric cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Tumor-Specific Peptide, Selected from a Phage Peptide Library, Enhances Antitumor Activity of Lactaptin.PloS one · 2016Article
- Assessing the clinical value of targeted massively parallel sequencing in a longitudinal, prospective population-based study of cancer patients.British journal of cancer · 2015Article
- Simulated annealing based algorithm for identifying mutated driver pathways in cancer.BioMed research international · 2014Article
- Global analysis of miRNA gene clusters and gene families reveals dynamic and coordinated expression.BioMed research international · 2014Article
- Multi-layered cancer chromosomal instability phenotype.Frontiers in oncology · 2013Review
- Article
- Isoform level expression profiles provide better cancer signatures than gene level expression profiles.Genome medicine · 2013Article
- The role of chromosome missegregation in cancer development: a theoretical approach using agent-based modelling.PloS one · 2013Article
- Epigenetics advancing personalized nanomedicine in cancer therapy.Advanced drug delivery reviews · 2012Review
- Interrelationship between microsatellite instability and microRNA in gastrointestinal cancer.World journal of gastroenterology · 2012Review
- Biomarker robustness reveals the PDGF network as driving disease outcome in ovarian cancer patients in multiple studies.BMC systems biology · 2012Article
- Article
- Identification of a chrXq27.3 microRNA cluster associated with early relapse in advanced stage ovarian cancer patients.Oncotarget · 2011Article
- The breast cancer genome--a key for better oncology.BMC cancer · 2011Review
- Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2011Article
- Insight into the heterogeneity of breast cancer through next-generation sequencing.The Journal of clinical investigation · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The last decade has witnessed unprecedented developments in the genetic and epigenetic analyses of solid tumours. Transcriptional and DNA copy-number studies have improved our understanding and classification of solid tumours and highlighted the patterns of genomic aberrations associated with outcome. The identification of altered transcriptional and translational silencing by microRNAs and epigenetic modification by methylation in tumours has showed a layer of additional intricacy to the regulation of gene expression in different tumour types. The advent of massive parallel sequencing has allowed whole cancer genomes to be sequenced with extraordinary speed and accuracy providing insight into the bewildering complexity of gene mutations present in solid tumours. Functional genomic studies using RNA interference-screening tools promises to improve the classification of solid tumours by probing the relevance of each gene to tumour phenotype. In this review, we discuss how these studies have contributed to solid tumour classification and why such studies are central to the future of oncology. We suggest that these developments are gradually leading to a change in emphasis of early clinical trials to a therapeutic model guided by the molecular classification of tumours. The investigation of drug efficacy later in development is beginning to rely on patient selection defined by predictive molecular criteria that complement solid tumour classification based on anatomic site.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.