ArticleProceedings of the Japan Academy. Series B, Physical and biological sciences2009
Aberrant promoter methylation and expression of the imprinted PEG3 gene in glioma.
Article in Proceedings of the Japan Academy. Series B, Physical and biological sciences, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Aberrations of Genomic Imprinting in Glioblastoma Formation.Frontiers in oncology · 2021Review
- PEG3 mutation is associated with elevated tumor mutation burden and poor prognosis in breast cancer.Bioscience reports · 2020Article
- M2 bone marrow-derived macrophage-derived exosomes shuffle microRNA-21 to accelerate immune escape of glioma by modulating PEG3.Cancer cell international · 2020Article
- Role of the zinc finger and SCAN domain-containing transcription factors in cancer.American journal of cancer research · 2019Review
- DNA methylation of imprinted genes in Mexican-American newborn children with prenatal phthalate exposure.Epigenomics · 2018Article
- Genomic Imprinting and the Regulation of Postnatal Neurogenesis.Brain plasticity (Amsterdam, Netherlands) · 2017Review
- Human exposure to flame-retardants is associated with aberrant DNA methylation at imprinted genes in sperm.Environmental epigenetics · 2017Article
- Newborns of obese parents have altered DNA methylation patterns at imprinted genes.International journal of obesity (2005) · 2015Article
- High grade glioblastoma is associated with aberrant expression of ZFP57, a protein involved in gene imprinting, and of CPT1A and CPT1C that regulate fatty acid metabolism.Cancer biology & therapy · 2014Article
- Article
- Specific changes in the expression of imprinted genes in prostate cancer--implications for cancer progression and epigenetic regulation.Asian journal of andrology · 2012Review
- Oncogenic potential of yin yang 1 mediated through control of imprinted genes.Critical reviews in oncogenesis · 2011Review
- Methylation profiling identifies 2 groups of gliomas according to their tumorigenesis.Neuro-oncology · 2011Article
- Circadian variations in gene expression in rat abdominal adipose tissue and relationship to physiology.Physiological genomics · 2010Article
- Epigenetics of neurological cancers.Future oncology (London, England) · 2009Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glioma includes astrocytoma, oligodendroglioma, ependymoma and glioblastoma. We previously reported the epigenetic silencing of paternally expressed gene 3 (PEG3) in glioma cell lines. In this study, we investigated methylation of an exonic CpG island in the promoter region and the expression of PEG3 gene in 20 glioma and 5 non-tumor tissue samples. We found wide variations in the methylation level. Hypomethylaiton and hypermethylation was found in 3 and 4 glioma tissue samples, respectively. Monoallelic expression, which is an evidence of an imprinted gene, was maintained in eight out of nine informative cases which have T/C polymorphisms in PEG3. The lower gene expression, which suggested epigenetic silencing of PEG3, was confirmed statistically in glioblastoma using quantitative reverse-transcription polymerase chain reaction. Interestingly, we found higher expression of PEG3 in two out of three oligodendrogliomas. A negative correlation between the methylation level and gene expression was shown by regression analysis. These results suggest that the abnormal regulation of PEG3 is associated with several glioma subtypes and that it plays an important role in tumorigenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.