ArticleSchizophrenia bulletin2010
Autonomic dysfunction in unaffected first-degree relatives of patients suffering from schizophrenia.
Article in Schizophrenia bulletin, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 79 citations in OpenAlex.
- Polygenic risk for psychotic disorders in relation to cardiac autonomic dysfunction in unmedicated patients with schizophrenia.European archives of psychiatry and clinical neuroscience · 2025Article
- Characterization of cardiac autonomic dysfunction in acute Schizophrenia: a cluster analysis of heart rate variability parameters.Schizophrenia (Heidelberg, Germany) · 2025Article
- Disrupted coherence between autonomic activation and emotional expression in individuals at clinical high risk for psychosis.Journal of psychopathology and clinical science · 2024Article
- Article
- Analysis ofGenes · 2022Article
- An integrative study of the microbiome gut-brain-axis and hippocampal inflammation in psychosis: Persistent effects from mode of birth.Schizophrenia research · 2022Article
- Heart Rate Variability in Schizophrenia and Autism.Frontiers in psychiatry · 2021Article
- Intranasal oxytocin increases heart-rate variability in men at clinical high risk for psychosis: a proof-of-concept study.Translational psychiatry · 2020Article
- The Cardiorespiratory Network in Healthy First-Degree Relatives of Schizophrenic Patients.Frontiers in neuroscience · 2020Article
- Early Signs of Schizophrenia and Autonomic Nervous System Dysregulation: A Literature Review.Clinical neuropsychiatry · 2019Article
- Aberrant parasympathetic reactivity to acute psychosocial stress in male patients with schizophrenia spectrum disorders.Psychiatry research · 2018Article
- Abdominal Vagal Afferents Modulate the Brain Transcriptome and Behaviors Relevant to Schizophrenia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Clozapine-Induced Cardiovascular Side Effects and Autonomic Dysfunction: A Systematic Review.Frontiers in neuroscience · 2018Article
- QT interval variability in body surface ECG: measurement, physiological basis, and clinical value: position statement and consensus guidance endorsed by the European Heart Rhythm Association jointly with the ESC Working Group on Cardiac Cellular Electrophysiology.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2016Article
- High-resolution joint symbolic analysis to enhance classification of the cardiorespiratory system in patients with schizophrenia and their relatives.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2015Article
- Etiology of cardiovascular disease in patients with schizophrenia: current perspectives.Neuropsychiatric disease and treatment · 2015Review
- Cardiac Autonomic Dysfunction in Patients with Schizophrenia and Their Healthy Relatives - A Small Review.Frontiers in neurology · 2015Review
- Distress intolerance and clinical functioning in persons with schizophrenia.Psychiatry research · 2014Article
- Social cognition and functional outcome in schizophrenia: The moderating role of cardiac vagal tone.Journal of abnormal psychology · 2014Article
- From the heart to the mind: cardiac vagal tone modulates top-down and bottom-up visual perception and attention to emotional stimuli.Frontiers in psychology · 2014Review
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent studies revealed cardiac autonomic dysfunction in patients with acute schizophrenia, which appears to be mainly related to reduced vagal and increased sympathetic modulation. To understand the significance of cardiac autonomic function in patients with schizophrenia, we extended these studies to relatives of patients. In this study, we assessed cardiac autonomic modulation in healthy first-degree relatives of patients with schizophrenia (n = 36) to investigate a putative genetic influence. Data were compared with control subjects matched for age, gender, and physical activity as well as to patients suffering from schizophrenia. First-degree relatives showed an attenuated, yet identical pattern in autonomic dysfunction as patients with decreased vagal modulation of heart rate, decreased baroreflex sensitivity, but no difference in blood pressure variability could be detected. The patients' relatives also showed a similar pattern in regards to QT variability. In addition, the subgroup comparison of offspring vs. siblings showed a significant difference in heart rate variability suggesting a higher degree of heritability in offspring. In conclusion, the pattern of autonomic dysfunction seen in patients and relatives might indicate underlying disease-inherent genetic vulnerability, especially because autonomic parameters are heritable. In addition, these findings may be of value to identify the high-risk group of patients' relatives in regards to serious cardiovascular events so that early preventive measures can be taken.
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